Isosteviol Sodium Promotes Neurological Function Recovery in a Model of Spinal Cord Injury in Rats

IF 3.1 4区医学 Q3 IMMUNOLOGY Immunity, Inflammation and Disease Pub Date : 2025-01-09 DOI:10.1002/iid3.70110

Tongxia Zhang, Tao Zhang, Han Yu, Lingyi Chi

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Abstract

Background

Traumatic spinal cord injury (SCI) is an incurable condition that is the largest cause of disability. In previous studies, Isosteviol sodium (STVNa) has been shown to protect rats against acute focal cerebral ischemia; however, the effects of STVNa on SCI recovery in rats remain unknown.

Methods

STVNa was given intraperitoneally after SCI to see if it had any neuroprotective benefits. On Days 7, 14, 21, and 28 post-SCI, functional recovery was measured using the Basso, Beattie, and Bresnahan (BBB) scoring system along with the oblique plate test. Following these evaluations, spinal cord tissues were harvested for analysis. All behavioral testing occurred between 8 a.m. and 3 p.m.

Results

We found that STVNa improved spinal cord functional recovery in rats, as evidenced by enhanced BBB locomotor rating scale, angle of inclination, decreased cavity of spinal cord damage, and neuron death in vivo. In addition, STVNa reduced inflammation in rats following SCI, as demonstrated by a reduction in proinflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-6, and interleukin (IL)-1β. STVNa also reduced oxidative damage in SCI rats by lowering ROS while raising SOD levels.

Conclusion

These findings suggest that STVNa protects SCI rats through a variety of pathways. STVNa, in particular, may benefit the recovery of SCI by reducing oxidative stress and inflammation, leading to enhanced locomotor activity in rats with SCI.

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异甜菊醇钠促进大鼠脊髓损伤模型的神经功能恢复。

背景：外伤性脊髓损伤（SCI）是一种无法治愈的疾病，是导致残疾的最大原因。在先前的研究中，异甜菊醇钠（STVNa）已被证明可以保护大鼠免受急性局灶性脑缺血；然而，STVNa对大鼠脊髓损伤恢复的影响尚不清楚。方法：脊髓损伤后腹腔注射STVNa，观察其是否有神经保护作用。在脊髓损伤后第7、14、21和28天，使用Basso、Beattie和Bresnahan （BBB）评分系统和斜板测试测量功能恢复情况。在这些评估之后，采集脊髓组织进行分析。所有的行为测试都发生在早上8点。下午3点。结果：我们发现STVNa能促进大鼠脊髓功能恢复，表现为血脑屏障运动评分、倾斜角度增强、脊髓损伤腔减少和神经元死亡。此外，STVNa减少了脊髓损伤后大鼠的炎症，如肿瘤坏死因子(TNF)-α，白细胞介素(IL)-6和白细胞介素(IL)-1β等促炎细胞因子的减少。STVNa还通过降低ROS和提高SOD水平来减轻脊髓损伤大鼠的氧化损伤。结论：这些发现提示STVNa通过多种途径保护脊髓损伤大鼠。特别是STVNa可能通过减少氧化应激和炎症，从而增强脊髓损伤大鼠的运动活性，从而有利于脊髓损伤的恢复。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Immunity, Inflammation and Disease Medicine-Immunology and Allergy

CiteScore

3.60

自引率

0.00%

发文量

146

审稿时长

8 weeks

期刊介绍： Immunity, Inflammation and Disease is a peer-reviewed, open access, interdisciplinary journal providing rapid publication of research across the broad field of immunology. Immunity, Inflammation and Disease gives rapid consideration to papers in all areas of clinical and basic research. The journal is indexed in Medline and the Science Citation Index Expanded (part of Web of Science), among others. It welcomes original work that enhances the understanding of immunology in areas including: • cellular and molecular immunology • clinical immunology • allergy • immunochemistry • immunogenetics • immune signalling • immune development • imaging • mathematical modelling • autoimmunity • transplantation immunology • cancer immunology