Recurrence of chronic lymphatic leukemia as infiltration of the spinal cord.

Q3 Medicine Journal of Medicine and Life Pub Date : 2024-11-01 DOI:10.25122/jml-2024-0321
Josef Finsterer, Victor Rathkolb
{"title":"Recurrence of chronic lymphatic leukemia as infiltration of the spinal cord.","authors":"Josef Finsterer, Victor Rathkolb","doi":"10.25122/jml-2024-0321","DOIUrl":null,"url":null,"abstract":"<p><p>Central nervous system (CNS) involvement in chronic lymphocytic leukemia (CLL) is rare, and spinal cord infiltration as a presenting manifestation has only rarely been described. We present the case of a 65-year-old man with CLL, initially diagnosed at the age of 54, who had not received prior treatment. He presented with a six-week history of thoracic and epigastric pressure. Mild ataxia was found in the clinical exam. Clinical evaluation revealed leukocytosis (163 G/L; normal range: 4-10 G/L). MRI of the spine showed a mildly enhancing, T2 hyperintense central lesion extending between C3 and T8. There was a pleocytosis of 105 /micro/l consisting of neoplastic B-lymphocytes. The bone marrow biopsy diagnosed a relapse of CLL, and the patient was started on ibrutinib, which had a positive effect. This case highlights spinal cord infiltration as a rare initial manifestation of CLL relapse, presenting with non-specific symptoms such as thoracic and epigastric pressure and mild spinal ataxia.</p>","PeriodicalId":16386,"journal":{"name":"Journal of Medicine and Life","volume":"17 11","pages":"1020-1022"},"PeriodicalIF":0.0000,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11705477/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Medicine and Life","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.25122/jml-2024-0321","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0

Abstract

Central nervous system (CNS) involvement in chronic lymphocytic leukemia (CLL) is rare, and spinal cord infiltration as a presenting manifestation has only rarely been described. We present the case of a 65-year-old man with CLL, initially diagnosed at the age of 54, who had not received prior treatment. He presented with a six-week history of thoracic and epigastric pressure. Mild ataxia was found in the clinical exam. Clinical evaluation revealed leukocytosis (163 G/L; normal range: 4-10 G/L). MRI of the spine showed a mildly enhancing, T2 hyperintense central lesion extending between C3 and T8. There was a pleocytosis of 105 /micro/l consisting of neoplastic B-lymphocytes. The bone marrow biopsy diagnosed a relapse of CLL, and the patient was started on ibrutinib, which had a positive effect. This case highlights spinal cord infiltration as a rare initial manifestation of CLL relapse, presenting with non-specific symptoms such as thoracic and epigastric pressure and mild spinal ataxia.

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
慢性淋巴白血病脊髓浸润复发。
慢性淋巴细胞白血病(CLL)的中枢神经系统(CNS)受累是罕见的,脊髓浸润作为一种表现也很少被描述。我们提出一个65岁的CLL患者的病例,最初诊断为54岁,之前没有接受过治疗。他有6周的胸压和上胃压病史。临床检查发现轻度共济失调。临床评价:白细胞增多(163 G/L;正常范围:4- 10g /L)。脊柱MRI显示轻度强化,T2高强度中央病变延伸至C3和T8之间。肿瘤性b淋巴细胞增生105 /微/l。骨髓活检诊断为CLL复发,患者开始使用依鲁替尼,效果良好。本病例强调脊髓浸润是CLL复发的罕见初始表现,表现为非特异性症状,如胸压、上胃压和轻度脊柱共济失调。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
相关文献
Role of mood stabilizers in bipolar disorder.
IF 4.3 2区 医学Expert Review of NeurotherapeuticsPub Date : 2002-03-01 DOI: 10.1586/14737175.2.2.239
Zubin Bhagwagar, Guy M Goodwin
来源期刊
Journal of Medicine and Life
Journal of Medicine and Life Medicine-Medicine (all)
CiteScore
1.90
自引率
0.00%
发文量
202
期刊介绍: The Journal of Medicine and Life publishes peer-reviewed articles from various fields of medicine and life sciences, including original research, systematic reviews, special reports, case presentations, major medical breakthroughs and letters to the editor. The Journal focuses on current matters that lie at the intersection of biomedical science and clinical practice and strives to present this information to inform health care delivery and improve patient outcomes. Papers addressing topics such as neuroprotection, neurorehabilitation, neuroplasticity, and neuroregeneration are particularly encouraged, as part of the Journal''s continuous interest in neuroscience research. The Editorial Board of the Journal of Medicine and Life is open to consider manuscripts from all levels of research and areas of biological sciences, including fundamental, experimental or clinical research and matters of public health. As part of our pledge to promote an educational and community-building environment, our issues feature sections designated to informing our readers regarding exciting international congresses, teaching courses and relevant institutional-level events.
期刊最新文献
The dual impact of social media: evolving beauty perceptions and cosmetic procedure practices among patients and providers. The role of dentate status and dental caries on diabetes-related complications: a hospital-based cross-sectional study. The transformative power of mHealth apps: empowering patients with obesity and diabetes - a narrative review. Assessment of pain intensity after total hip arthroplasty using the Visual Analogue Scale (VAS). Barriers facing emergency physicians in providing urgent care to pediatric patients in Saudi Arabia - a cross-sectional study.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1