Application of Network Pharmacology in the Treatment of Neurodegenerative Diseases with Traditional Chinese Medicine.

IF 2.1 4区医学 Q3 CHEMISTRY, MEDICINAL Planta medica Pub Date : 2025-02-18 DOI:10.1055/a-2512-8928

Qiang Chen, Guanghui Chen, Qianyan Wang

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Abstract

In recent years, the incidence of neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis, has exhibited a steadily rising trend, which has posed a major challenge to the global public health. Traditional Chinese medicine, with its multicomponent and multitarget characteristics, offers a promising approach to treating neurodegenerative diseases. However, comprehensively elucidating the complex mechanisms underlying traditional Chinese medicine formulations remains challenging. As an emerging systems biology method, network pharmacology has provided a vital tool for revealing the multitarget mechanisms of traditional Chinese medicine through high-throughput technologies, molecular docking, and network analysis. This paper reviews the advancements in the application of network pharmacology in treating neurodegenerative diseases using traditional Chinese medicine, analyzes the current status of relevant databases and technological methods, discusses the limitations, and proposes future directions to promote the modernization of traditional Chinese medicine and the development of precision medicine.

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网络药理学在中医治疗神经退行性疾病中的应用。

近年来，阿尔茨海默病、帕金森病、亨廷顿病、肌萎缩侧索硬化症等神经退行性疾病的发病率呈稳步上升趋势，对全球公共卫生构成重大挑战。中医以其多成分、多靶点的特点，为神经退行性疾病的治疗提供了一条有前景的途径。然而，很难全面阐明中药配方的复杂机制。网络药理学作为一种新兴的系统生物学方法，通过高通量技术、分子对接和网络分析为揭示中药多靶点机制提供了重要工具。本文综述了网络药理学在中医治疗神经退行性疾病中的应用进展，分析了相关数据库和技术方法的现状，讨论了研究中的局限性，并提出了促进中医现代化和精准医学发展的未来方向。关键词：神经退行性疾病，中医，网络药理学，治疗靶点

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来源期刊

Planta medica 医学-药学

CiteScore

5.10

自引率

3.70%

发文量

101

审稿时长

1.8 months

期刊介绍： Planta Medica is one of the leading international journals in the field of natural products – including marine organisms, fungi as well as micro-organisms – and medicinal plants. Planta Medica accepts original research papers, reviews, minireviews and perspectives from researchers worldwide. The journal publishes 18 issues per year. The following areas of medicinal plants and natural product research are covered: -Biological and Pharmacological Activities -Natural Product Chemistry & Analytical Studies -Pharmacokinetic Investigations -Formulation and Delivery Systems of Natural Products. The journal explicitly encourages the submission of chemically characterized extracts.