Suma Thareja, Elizabeth Lucero, Aparna Ramasubramanian
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引用次数: 0
Abstract
Purpose: To examine propranolol efficacy in treating diffuse (DCH) and circumscribed choroidal hemangiomas (CCH) and controlling intraocular pressure (IOP) in patients with Sturge-Weber syndrome (SWS).
Methods: A SWS patient case treated with propranolol for DCH is presented. Following PRISMA guidelines, we also performed a systematic review using PubMed/Web of Science, analyzing 14 studies detailing propranolol treatment outcomes for DCH, CCH, and IOP control in SWS. Demographic, clinical, treatment, and outcome data were extracted and statistically analyzed. Fisher's exact test was used to compare findings such as retinal detachment rates.
Results: We reviewed patients treated with propranolol, including 8 DCH, 18 CCH, and 16 SWS cases of IOP control. Retinal detachment rates were significantly higher in DCH compared to CCH cases. Post-propranolol, 73% of DCH and CCH cases showed subretinal fluid improvement, and in SWS patients, 94% had IOP reduction.
Conclusion: This study underscores the potential utility of propranolol beyond its traditional use in cutaneous hemangioma for treatment of CCH/DCH and IOP control.
目的：观察普萘洛尔治疗斯特奇-韦伯综合征（SWS）患者弥漫性（DCH）和局限性脉络膜血管瘤（CCH）及控制眼压（IOP）的疗效。方法：报告1例SWS患者应用心得安治疗DCH。遵循PRISMA指南，我们还使用PubMed/Web of Science进行了系统综述，分析了14项研究，详细介绍了心得安治疗SWS患者DCH、CCH和IOP控制的结果。提取人口学、临床、治疗和结局数据并进行统计分析。Fisher的精确测试被用来比较视网膜脱离率等结果。结果：我们回顾了使用心得安治疗的患者，包括8例DCH， 18例CCH和16例SWS IOP控制。DCH的视网膜脱离率明显高于CCH。服用心得安后，73%的DCH和CCH患者视网膜下积液改善，而在SWS患者中，94%的IOP降低。结论：本研究强调了心得安在皮肤血管瘤治疗CCH/DCH和眼压控制方面的潜在应用价值。
期刊介绍：
Seminars in Ophthalmology offers current, clinically oriented reviews on the diagnosis and treatment of ophthalmic disorders. Each issue focuses on a single topic, with a primary emphasis on appropriate surgical techniques.
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