Exosomes of stem cells: a potential frontier in the treatment of osteoarthritis.

IF 5 4区 医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL Precision Clinical Medicine Pub Date : 2024-11-26 eCollection Date: 2025-03-01 DOI:10.1093/pcmedi/pbae032
Xiaofei Wang, Lei Xu, Zhimin Wu, Linbing Lou, Cunyi Xia, Haixiang Miao, Jihang Dai, Wenyong Fei, Jingcheng Wang
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Abstract

The aging population has led to a global issue of osteoarthritis (OA), which not only impacts the quality of life for patients but also poses a significant economic burden on society. While biotherapy offers hope for OA treatment, currently available treatments are unable to delay or prevent the onset or progression of OA. Recent studies have shown that as nanoscale bioactive substances that mediate cell communication, exosomes from stem cell sources have led to some breakthroughs in the treatment of OA and have important clinical significance. This paper summarizes the mechanism and function of stem cell exosomes in delaying OA and looks forward to the development prospects and challenges of exosomes.

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干细胞外泌体:骨关节炎治疗的潜在前沿。
人口老龄化导致骨关节炎(OA)成为一个全球性问题,不仅影响患者的生活质量,也给社会带来了巨大的经济负担。虽然生物疗法为OA治疗提供了希望,但目前可用的治疗方法无法延迟或预防OA的发病或进展。近年来的研究表明,干细胞来源的外泌体作为介导细胞通讯的纳米级生物活性物质,在OA治疗方面取得了一些突破,具有重要的临床意义。本文综述了干细胞外泌体延缓OA的机制和作用,并展望了外泌体的发展前景和挑战。
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来源期刊
Precision Clinical Medicine
Precision Clinical Medicine MEDICINE, RESEARCH & EXPERIMENTAL-
CiteScore
10.80
自引率
0.00%
发文量
26
审稿时长
5 weeks
期刊介绍: Precision Clinical Medicine (PCM) is an international, peer-reviewed, open access journal that provides timely publication of original research articles, case reports, reviews, editorials, and perspectives across the spectrum of precision medicine. The journal's mission is to deliver new theories, methods, and evidence that enhance disease diagnosis, treatment, prevention, and prognosis, thereby establishing a vital communication platform for clinicians and researchers that has the potential to transform medical practice. PCM encompasses all facets of precision medicine, which involves personalized approaches to diagnosis, treatment, and prevention, tailored to individual patients or patient subgroups based on their unique genetic, phenotypic, or psychosocial profiles. The clinical conditions addressed by the journal include a wide range of areas such as cancer, infectious diseases, inherited diseases, complex diseases, and rare diseases.
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