Street Pharmacology: Toxico-Dermatology of Injection Drug Use

David F. Lehmann PharmD, MD, Aryana Nazem BS, Jeanna Marraffa PharmD, MPH, DABAT, FAACT, Ramsay Sami Farah MD
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Abstract

Street medicine is a point-of-care, mobile approach that services the needs of unhoused individuals who are otherwise unable to access medical care in traditional settings. The prevalence of injection drug use combines with the pipeline of illicit substances, to produce a constellation of severe, potentially life-threatening dermatological disorders unique to this population. This review applies principles of clinical pharmacology to clarify the mechanisms underlying the dermatological toxicity of xylazine, desomorphine, and 3,4-methylenedioxymethamphetamine (MDMA).

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街头药理学:注射用药的毒理学-皮肤病学。
街头医疗是一种即时护理的流动方法,可满足在传统环境中无法获得医疗服务的无家可归者的需求。注射吸毒的流行与非法药物的流通相结合,产生了这一人群特有的一系列严重的、可能危及生命的皮肤病。本文运用临床药理学原理阐明了噻嗪、去吗啡和3,4-亚甲基二氧基甲基苯丙胺(MDMA)皮肤毒性的机制。
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