Functional Role of miR-499a-5p in the Development of Gastric Cancer.

IF 1.4 4区 医学 Q4 GASTROENTEROLOGY & HEPATOLOGY Turkish Journal of Gastroenterology Pub Date : 2024-12-16 DOI:10.5152/tjg.2024.24429
Cuiling Lu, Chengwang Guo, Cuihua Wu, Zhang Liping, Xiaoling Liu, Shoucun Guo
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引用次数: 0

Abstract

Gastric cancer (GC) is a highly prone malignant tumor, which has attracted wide attention. This study investigated the expression and clinical value of miR-499a-5p in GC. A total of 105 patients with GC were included in this study. Simultaneously, 55 patients with benign stomach disorders and 45 healthy subjects were enrolled as controls. Real-time quantitative polymerase chain reaction was used to determine the expression of miR-499a-5p. The receiver operating characteristic curve was used to assess the diagnostic value of miR-499a-5p in GC. Kaplan-Meier and logistic analyses were used to evaluate the association between miR-499a-5p and GC prognosis. The levels of miR-499a-5p are markedly downregulated in GC and have a high diagnostic value. miR-499a-5p is closely linked to pathological features of GC. Overexpression of miR-499a-5p inhibits GC cell growth, migration, and invasion. Furthermore, miR499a-5p is also related to GC and 5-year survival, and is a risk factor for GC death. The levels of miR-499a-5p were markedly downregulated in GC and related to GC pathological features. It has the potential to become a biomarker for the diagnosis of GC.

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miR-499a-5p在胃癌发生发展中的功能作用
胃癌(Gastric cancer, GC)是一种高发的恶性肿瘤,引起了人们的广泛关注。本研究探讨miR-499a-5p在胃癌中的表达及临床价值。本研究共纳入105例胃癌患者。同时,55名良性胃疾病患者和45名健康受试者作为对照。采用实时定量聚合酶链反应检测miR-499a-5p的表达。采用受试者工作特征曲线评价miR-499a-5p在GC中的诊断价值。采用Kaplan-Meier和logistic分析评估miR-499a-5p与胃癌预后的相关性。miR-499a-5p水平在GC中明显下调,具有较高的诊断价值。miR-499a-5p与GC的病理特征密切相关。过表达miR-499a-5p可抑制GC细胞的生长、迁移和侵袭。此外,miR499a-5p还与GC和5年生存率相关,是GC死亡的危险因素。miR-499a-5p水平在GC中明显下调,并与GC病理特征相关。它有可能成为胃癌诊断的生物标志物。
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来源期刊
Turkish Journal of Gastroenterology
Turkish Journal of Gastroenterology 医学-胃肠肝病学
CiteScore
1.90
自引率
0.00%
发文量
127
审稿时长
6 months
期刊介绍: The Turkish Journal of Gastroenterology (Turk J Gastroenterol) is the double-blind peer-reviewed, open access, international publication organ of the Turkish Society of Gastroenterology. The journal is a bimonthly publication, published on January, March, May, July, September, November and its publication language is English. The Turkish Journal of Gastroenterology aims to publish international at the highest clinical and scientific level on original issues of gastroenterology and hepatology. The journal publishes original papers, review articles, case reports and letters to the editor on clinical and experimental gastroenterology and hepatology.
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