Role of MicroRNAs in regulating sarcoplasmic reticulum calcium handling and their implications for cardiomyocyte function and heart disease

IF 3.3 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS Current Problems in Cardiology Pub Date : 2025-01-07 DOI:10.1016/j.cpcardiol.2025.102980

Benjamin Alexander Carter, Victoria Elizabeth Parker

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Abstract

The regulation of calcium signaling within cardiomyocytes is pivotal for maintaining cardiac function, with disruptions in sarcoplasmic reticulum (SR) calcium handling linked to various heart diseases. This review explores the emerging role of microRNAs (miRNAs) in modulating SR calcium dynamics, highlighting their influence on cardiomyocyte maturation, function, and disease progression. We present a comprehensive overview of the mechanisms by which specific miRNAs, such as miR-1, miR-24, and miR-22, regulate key components of calcium handling, including ryanodine receptors, SERCA, and NCX. Notably, we identify critical research gaps, particularly the inconsistent findings regarding miRNA expression in heart disease and the need for standardized experimental conditions. Furthermore, we emphasize the potential of miRNAs as therapeutic targets, given their ability to influence calcium handling pathways and cardiac remodeling. The review also discusses the challenges in translating miRNA research into clinical applications, including the need for safe and effective delivery methods. By synthesizing current knowledge and identifying areas for future investigation, this review aims to provide insights into the therapeutic potential of miRNAs in diagnosing and treating heart diseases, ultimately contributing to improved patient outcomes.

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microrna在调节肌浆网钙处理中的作用及其对心肌细胞功能和心脏病的影响。

心肌细胞内钙信号的调节对于维持心脏功能至关重要，肌浆网（SR）钙处理的中断与各种心脏病有关。这篇综述探讨了microRNAs （miRNAs）在调节SR钙动力学中的新作用，强调了它们对心肌细胞成熟、功能和疾病进展的影响。我们全面概述了特定mirna的机制，如miR-1、miR-24和miR-22，调节钙处理的关键成分，包括ryanodine受体、SERCA和NCX。值得注意的是，我们确定了关键的研究空白，特别是关于心脏病中miRNA表达的不一致的发现和标准化实验条件的需求。此外，我们强调mirna作为治疗靶点的潜力，因为它们能够影响钙处理途径和心脏重塑。这篇综述还讨论了将miRNA研究转化为临床应用的挑战，包括对安全有效的递送方法的需求。通过综合目前的知识和确定未来研究的领域，本综述旨在深入了解mirna在诊断和治疗心脏病方面的治疗潜力，最终有助于改善患者的预后。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Problems in Cardiology 医学-心血管系统

CiteScore

4.80

自引率

2.40%

发文量

392

审稿时长

6 days

期刊介绍： Under the editorial leadership of noted cardiologist Dr. Hector O. Ventura, Current Problems in Cardiology provides focused, comprehensive coverage of important clinical topics in cardiology. Each monthly issues, addresses a selected clinical problem or condition, including pathophysiology, invasive and noninvasive diagnosis, drug therapy, surgical management, and rehabilitation; or explores the clinical applications of a diagnostic modality or a particular category of drugs. Critical commentary from the distinguished editorial board accompanies each monograph, providing readers with additional insights. An extensive bibliography in each issue saves hours of library research.