Factors of Long-Term Prognosis for Cardiovascular Complications in Patients After Acute Myocardial Infarction, Based on the Plasma Proteome.

IF 0.5 4区医学 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS Kardiologiya Pub Date : 2024-12-25 DOI:10.18087/cardio.2024.12.n2801

E L Kordzaya, A S Kononikhin, E N Nikolaev, E J Vasilieva, A A Komissarov

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Abstract

Aim: To study the plasma proteome of patients with type 1 acute myocardial infarction (AMI) to identify potential markers for long-term prognosis of the risk for developing cardiovascular complications.

Material and methods: The study included 64 patients with type 1 AMI with and without ST segment elevation who underwent primary percutaneous coronary intervention upon admission. The following information on cardiovascular events was collected for 36 months after admission: death from cardiovascular pathology, recurrent AMI, stroke, repeat myocardial revascularization and/or endarterectomy. Peripheral blood sampling followed by a plasma proteome analysis using chromatography-mass spectrometry was performed in all patients before hospitalization.

Results: During 36 months after hospitalization, cardiovascular complications were detected in 23 (36%) patients. These patients were included in the group with an unfavorable prognosis, while the remaining patients made up the group with a positive prognosis. A mass spectrometric analysis of the plasma proteome and comparison of the groups identified seven differentially represented proteins. Also, a multivariate regression analysis, ROC curves, and Kaplan-Meier models showed that four proteins (apolipoprotein C1, complement factor H, di-N-acetylchitobiase, and ficolin-2) were predictors of the risk for developing cardiovascular complications in the long term. An integrated parameter was developed that took into account the plasma concentrations of all four above proteins. This parameter was used to construct a model for assessing the risks of unfavorable long-term prognosis in AMI patients with a sensitivity of 87% and a specificity of 78%.

Conclusion: The study results demonstrated that plasma concentrations of apolipoprotein C1, complement factor H, di-N-acetylchitobiase, and ficolin-2 are reliable prognostic markers for assessing the risks of cardiovascular events in patients with AMI in the long term.

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基于血浆蛋白质组的急性心肌梗死后心血管并发症远期预后因素分析

目的：研究1型急性心肌梗死（AMI）患者的血浆蛋白质组学，以确定心血管并发症发生风险的长期预后指标。材料和方法：本研究纳入了64例1型AMI伴或不伴ST段抬高的患者，这些患者在入院时接受了经皮冠状动脉介入治疗。入院后36个月收集以下心血管事件信息：心血管病理死亡、AMI复发、卒中、重复心肌血运重建术和/或动脉内膜切除术。所有患者在住院前均进行外周血取样，随后采用色谱-质谱法进行血浆蛋白质组分析。结果：住院36个月，23例（36%）患者出现心血管并发症。这些患者被纳入预后不良组，其余患者组成预后良好组。血浆蛋白质组的质谱分析和组间比较鉴定出7种不同的蛋白质。此外，多变量回归分析、ROC曲线和Kaplan-Meier模型显示，四种蛋白（载脂蛋白C1、补体因子H、二n-乙酰壳聚糖酶和ficolin-2）是长期发生心血管并发症风险的预测因子。开发了一个综合参数，考虑到所有上述四种蛋白质的血浆浓度。利用该参数构建AMI患者不良长期预后风险评估模型，敏感性为87%，特异性为78%。结论：本研究结果表明，血浆载脂蛋白C1、补体因子H、二n-乙酰壳聚糖酶和ficolin-2浓度是评估AMI患者长期心血管事件风险的可靠预后指标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Kardiologiya 医学-心血管系统

CiteScore

1.70

自引率

20.00%

发文量

审稿时长

3-8 weeks

期刊介绍： “Kardiologiya” (Cardiology) is a monthly scientific, peer-reviewed journal committed to both basic cardiovascular medicine and practical aspects of cardiology. As the leader in its field, “Kardiologiya” provides original coverage of recent progress in cardiovascular medicine. We publish state-of-the-art articles integrating clinical and research activities in the fields of basic cardiovascular science and clinical cardiology, with a focus on emerging issues in cardiovascular disease. Our target audience spans a diversity of health care professionals and medical researchers working in cardiovascular medicine and related fields. The principal language of the Journal is Russian, an additional language – English (title, authors’ information, abstract, keywords). “Kardiologiya” is a peer-reviewed scientific journal. All articles are reviewed by scientists, who gained high international prestige in cardiovascular science and clinical cardiology. The Journal is currently cited and indexed in major Abstracting & Indexing databases: Web of Science, Medline and Scopus. The Journal''s primary objectives Contribute to raising the professional level of medical researchers, physicians and academic teachers. Present the results of current research and clinical observations, explore the effectiveness of drug and non-drug treatments of heart disease, inform about new diagnostic techniques; discuss current trends and new advancements in clinical cardiology, contribute to continuing medical education, inform readers about results of Russian and international scientific forums; Further improve the general quality of reviewing and editing of manuscripts submitted for publication; Provide the widest possible dissemination of the published articles, among the global scientific community; Extend distribution and indexing of scientific publications in major Abstracting & Indexing databases.