A retrospective comparative fractal and radiomorphometric analysis of the effect of bisphosphonate use pattern and duration on the mandible.

IF 1.6 3区医学 Q3 DENTISTRY, ORAL SURGERY & MEDICINE Oral Radiology Pub Date : 2025-01-08 DOI:10.1007/s11282-024-00801-2

Nida Geçkil, Katibe Tuğçe Temur

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Abstract

Aims: The aim of this study was to investigate the effect of two different bisphosphonate types on bone using dental panoramic radiographs (DPRs) and to compare these findings with a healthy cohort.

Study design: Panoramic dental radiographs of bisphosphonate users (30) and healthy individuals (30) were retrospectively evaluated for the study. Regarding FA, standardized 50 × 50 pixel regions of interest (ROI) were identified for each patient. Moreover, the assessment encompassed Mandibular Cortical Width (MCW), Panoramic Mandibular Index (PMI), and Mandibular Cortical Index (MCI). A significance level of p < 0.05 was deemed to be statistically significant.

Results: The case group showed significantly higher MCW and PMI measurements than the control group (p < 0.001). Right and left MCI measurements differed depending on the type of drug used (p = 0.008 and p = 0.019, respectively). No discernible correlation was found between the time elapsed since the last dose and any measurement values (p > 0.05).

Conclusion: This study showed that bisphosphonate type and duration of drug use have a significant effect on changes in cortical bone structure. The persistence of these effects, unaffected by the time since the previous dose, suggests that bisphosphonates have a long-lasting effect on bone.

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双膦酸盐使用方式和持续时间对下颌骨影响的回顾性比较分形和放射形态分析。

目的：本研究的目的是利用牙科全景x线片（DPRs）研究两种不同类型的双膦酸盐对骨骼的影响，并将这些结果与健康人群进行比较。研究设计：回顾性评价双膦酸盐使用者（30人）和健康个体（30人）的牙科全景x线片。对于FA，为每位患者确定标准化的50 × 50像素感兴趣区域（ROI）。此外，评估包括下颌皮质宽度（MCW），下颌全景指数（PMI）和下颌皮质指数（MCI）。结果：病例组的MCW和PMI测量值明显高于对照组（p 0.05）。结论：本研究表明，双膦酸盐类型和用药时间对皮质骨结构的改变有显著影响。这些影响的持续存在，不受上次剂量后时间的影响，表明双膦酸盐对骨骼有持久的影响。

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来源期刊

Oral Radiology DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

4.20

自引率

13.60%

发文量

审稿时长

>12 weeks

期刊介绍： As the official English-language journal of the Japanese Society for Oral and Maxillofacial Radiology and the Asian Academy of Oral and Maxillofacial Radiology, Oral Radiology is intended to be a forum for international collaboration in head and neck diagnostic imaging and all related fields. Oral Radiology features cutting-edge research papers, review articles, case reports, and technical notes from both the clinical and experimental fields. As membership in the Society is not a prerequisite, contributions are welcome from researchers and clinicians worldwide.