Sensitization to food allergens is associated with more severe wheezing in children.

Allergologie select Pub Date : 2024-12-31 eCollection Date: 2024-01-01 DOI:10.5414/ALX02546E

Ozge Yılmaz, Cecilia M Patino, Fatma Taneli, Esra Toprak Kanik, Ahmet Turkeli, Ceyhun Gozukara, Sezen Irmak, Hasan Yuksel

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Abstract

Aims: We investigated sensitization to food allergens as a prognostic factor for wheezing in children with recurrent wheezing and compared serum club cell 16 (CC16) and surfactant protein D (SP-D) among these children with and without sensitization to food allergens.

Materials and methods: Children with recurrent wheezing were enrolled in this prospective cohort study. Specific IgE to five common food allergens (Fx5) was assessed at baseline, and children were followed-up for 1 year for new-onset wheezing episodes. Baseline wheezing severity score, CC16, and SP-D levels were measured.

Results: We enrolled 295 children (44 Fx5(+)). Poisson regression analysis revealed that Fx5 positivity changed the yearly frequency of wheeze by a factor of 1.66 (p = 0.05, 95% CI: (0.99 - 2.75)). Levels of CC16 and SP-D were not significantly different between the groups (p = 0.679 and p = 0.988).

Conclusion: Sensitization to food allergens irrespective of food associated clinical allergy findings is associated with worse prognosis of wheezing in children.

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对食物过敏原的敏感与儿童更严重的喘息有关。

目的：我们研究了食物过敏原致敏作为复发性喘息儿童的预后因素，并比较了这些有和没有食物过敏原致敏的儿童的血清俱乐部细胞16 （CC16）和表面活性蛋白D （SP-D）。材料和方法：复发性喘息儿童被纳入这项前瞻性队列研究。在基线时评估对五种常见食物过敏原（Fx5）的特异性IgE，并对新发喘息发作的儿童进行1年随访。测量基线喘息严重程度评分、CC16和SP-D水平。结果：我们招募了295名儿童（44名Fx5(+)）。泊松回归分析显示，Fx5阳性改变喘息年频率的因子为1.66 （p = 0.05, 95% CI:(0.99 - 2.75)）。各组间CC16和SP-D水平差异无统计学意义（p = 0.679和p = 0.988）。结论：对食物过敏原的致敏与儿童喘息预后较差有关，而与食物相关的临床过敏结果无关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Allergologie select

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