Effects on neuroprotection and α-synuclein expression of a Canna coccinea rhizome extract

IF 2.5 3区 医学 Q3 CHEMISTRY, MEDICINAL Fitoterapia Pub Date : 2025-01-05 DOI:10.1016/j.fitote.2025.106380
Viviana G. Spotorno , Mariana Roxo , Bernhard Wetterauer , Osvaldo A. Zabal , Michael Wink
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Abstract

Parkinson's disease (PD) is the second most common neurodegenerative disorder in the elderly, currently with no cure. Its mechanisms are not well understood, however α-synuclein protein aggregation plays a central role in the pathogenesis of PD, leading to neurodegeneration. We demonstrated that in a PD model dietary in Caenorhabditis elegans treatment with an extract from the rhizome of Canna coccinea decreased the accumulation of α-synuclein. The extract showed low toxicity to neuro 2a cells and protected them from oxidative damage with H2O2 as a model for neurodegeneration. We studied the chemical profile of the extract using liquid chromatography couple to Mass Spectrometry. In order to characterize the herbal extract, we quantified rosmarinic acid as a marker compound and measured its antioxidant activity in vitro. Altogether, apart from its potential as a functional food, Canna coccinea may be an interesting source of secondary metabolites in the development of potential novel anti-neurodegenerative drugs.

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美人蕉根茎提取物对神经保护作用及α-突触核蛋白表达的影响。
帕金森病(PD)是老年人中第二大最常见的神经退行性疾病,目前尚无治愈方法。其机制尚不清楚,但α-突触核蛋白聚集在PD的发病机制中起核心作用,导致神经退行性变。我们证明,在一个PD模型中,用美人蕉根茎提取物治疗秀丽隐杆线虫可以减少α-突触核蛋白的积累。作为神经退行性疾病模型,该提取物对神经2a细胞显示出低毒性,并保护它们免受H2O2氧化损伤。我们利用液相色谱-质谱联用技术研究了提取物的化学成分。以迷迭香酸为标记物,对其体外抗氧化活性进行了测定。总之,除了作为功能性食品的潜力之外,美人蕉可能是开发潜在的新型抗神经退行性药物的次要代谢物的有趣来源。
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来源期刊
Fitoterapia
Fitoterapia 医学-药学
CiteScore
5.80
自引率
2.90%
发文量
198
审稿时长
1.5 months
期刊介绍: Fitoterapia is a Journal dedicated to medicinal plants and to bioactive natural products of plant origin. It publishes original contributions in seven major areas: 1. Characterization of active ingredients of medicinal plants 2. Development of standardization method for bioactive plant extracts and natural products 3. Identification of bioactivity in plant extracts 4. Identification of targets and mechanism of activity of plant extracts 5. Production and genomic characterization of medicinal plants biomass 6. Chemistry and biochemistry of bioactive natural products of plant origin 7. Critical reviews of the historical, clinical and legal status of medicinal plants, and accounts on topical issues.
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