Chronic rhinosinusitis with nasal polyps: Key considerations in the multidisciplinary team approach

IF 4.6 2区 医学 Q2 ALLERGY Clinical and Translational Allergy Pub Date : 2025-01-10 DOI:10.1002/clt2.70010
Oliver Pfaar, Anju T. Peters, Camille Taillé, Thijs Teeling, Jared Silver, Robert Chan, Peter W. Hellings
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Abstract

Background

Chronic rhinosinusitis with nasal polyps (CRSwNP) is a recurrent inflammatory disease associated with several comorbidities and a significant disease burden for patients. Treatments include corticosteroids and sinonasal surgery, but these can be associated with the risk of adverse events and nasal polyp recurrence. Biologic treatments such as mepolizumab can be used as an add-on treatment and are effective at reducing surgery and corticosteroid use.

Main text

Patients with CRSwNP may be seen by a specialist in one of several different areas and often experience delayed diagnosis due to the need to see multiple physicians, as well as misdiagnosis resulting from lack of sufficient expertise within any one speciality. Multidisciplinary team (MDT) approaches have been shown to be effective in optimising the treatment and clinical management of other respiratory diseases, such as aspirin-exacerbated respiratory disease and severe asthma. In CRSwNP, an MDT approach may reduce diagnostic delays, mitigate secondary disease burden, and reduce overprescription of corticosteroids and antibiotics.

Conclusion

This article provides an overview of the patient perspective of MDTs, existing approaches and barriers to adoption, lessons learnt from allied and rare diseases, how to address under-recognised aspects of CRSwNP, and other key considerations for developing an MDT approach.

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慢性鼻窦炎伴鼻息肉:多学科团队方法的关键考虑因素。
背景:慢性鼻窦炎伴鼻息肉(CRSwNP)是一种复发性炎症性疾病,与多种合并症相关,是患者的重要疾病负担。治疗方法包括皮质类固醇和鼻窦手术,但这些可能与不良事件和鼻息肉复发的风险相关。生物治疗如mepolizumab可以作为附加治疗,有效减少手术和皮质类固醇的使用。患有CRSwNP的患者可能会在几个不同领域的专家那里就诊,并且由于需要看多名医生,以及由于缺乏足够的专业知识而导致的误诊,通常会经历延迟诊断。多学科团队(MDT)方法已被证明在优化其他呼吸系统疾病的治疗和临床管理方面是有效的,例如阿司匹林加重的呼吸系统疾病和严重哮喘。在CRSwNP中,MDT方法可以减少诊断延迟,减轻继发性疾病负担,减少皮质类固醇和抗生素的过度处方。结论:本文概述了患者对MDT的看法、现有方法和采用障碍、从相关疾病和罕见疾病中吸取的经验教训、如何解决CRSwNP未被认识的方面,以及开发MDT方法的其他关键考虑因素。
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来源期刊
Clinical and Translational Allergy
Clinical and Translational Allergy Immunology and Microbiology-Immunology
CiteScore
7.50
自引率
4.50%
发文量
117
审稿时长
12 weeks
期刊介绍: Clinical and Translational Allergy, one of several journals in the portfolio of the European Academy of Allergy and Clinical Immunology, provides a platform for the dissemination of allergy research and reviews, as well as EAACI position papers, task force reports and guidelines, amongst an international scientific audience. Clinical and Translational Allergy accepts clinical and translational research in the following areas and other related topics: asthma, rhinitis, rhinosinusitis, drug hypersensitivity, allergic conjunctivitis, allergic skin diseases, atopic eczema, urticaria, angioedema, venom hypersensitivity, anaphylaxis, food allergy, immunotherapy, immune modulators and biologics, animal models of allergic disease, immune mechanisms, or any other topic related to allergic disease.
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