Juanjuan Li, Wenyi Xiao, Lijuan Wang, Miao Zhang, Yurong Ge
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引用次数: 0
Abstract
Background: To evaluate the epidemiological data on the prevalence of frailty and prefrailty in individuals aged 60 years or older on MHD patients.
Methods: PubMed, Web of Science, Embase, CNKI, WanFang, CBM, and VIP were searched from inception to February 2023 using combinations of subject words and free words. The methodological quality of all the selected studies was assessed using the Joanna Briggs Institute Critical Appraisal of Epidemiological Studies Checklist and Newcastle‒Ottawa Cohort Quality Assessment Scale. Random effects meta-analysis was used to pool estimates from different studies. Subgroup analysis and meta-regression were performed to explore potential sources of heterogeneity.
Results: Of the 4,190 documents retrieved, 16 observational studies involving 2,446 participants from 8 countries were included in this systematic review. Among older adults receiving MHD, the overall prevalence of frailty and prefrailty was 41% (95% CI = 34-49%) and 37% (95% CI = 26-48%), respectively, with considerable heterogeneity. The pooled prevalence of frailty was greater among individuals aged > 70 years (45%) than among those aged ≤ 70 years (37%). However, subgroup analyses indicated that the confidence intervals for the age group overlap substantially.
Conclusion: Our research showed that the prevalence of frailty and prefrailty in older patients with MHD are high.
Trial registration: The PROSPERO registration number for this study was CRD42023442569.
背景：评价60岁及以上MHD患者虚弱和易患性的流行病学资料。方法：采用主题词和自由词组合检索自建站至2023年2月的PubMed、Web of Science、Embase、CNKI、万方、CBM和VIP。所有入选研究的方法学质量均采用乔安娜布里格斯研究所流行病学研究关键评估清单和纽卡斯尔-渥太华队列质量评估量表进行评估。随机效应荟萃分析用于汇总来自不同研究的估计。采用亚组分析和元回归来探索潜在的异质性来源。结果：在检索到的4190篇文献中，16项观察性研究纳入了来自8个国家的2446名参与者。在接受MHD治疗的老年人中，虚弱和虚弱的总体患病率分别为41% （95% CI = 34-49%）和37% (95% CI = 26-48%)，具有相当大的异质性。年龄在70岁至70岁之间的人（45%）比年龄≤70岁的人（37%）更容易出现虚弱。然而，亚组分析表明，年龄组的置信区间有很大的重叠。结论：我们的研究表明，老年MHD患者的虚弱和易患性患病率较高。试验注册：本研究的PROSPERO注册号为CRD42023442569。
期刊介绍：
BMC Nephrology is an open access journal publishing original peer-reviewed research articles in all aspects of the prevention, diagnosis and management of kidney and associated disorders, as well as related molecular genetics, pathophysiology, and epidemiology.
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