Impact of Probiotics on Triglyceride Level After Bariatric Surgery: A Trial Sequential Analysis.

IF 2.9 3区医学 Q1 SURGERY Obesity Surgery Pub Date : 2025-02-01 Epub Date: 2025-01-11 DOI:10.1007/s11695-025-07670-6

I-Wen Chen, Kuo-Chuan Hung

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Abstract

This meta-analysis and trial sequential analysis (TSA) investigated the effects of probiotic supplementation on triglyceride levels in patients after bariatric surgery. A comprehensive literature search identified seven randomized controlled trials involving 411 participants. The meta-analysis revealed a significant reduction in triglyceride levels favoring probiotic supplementation (mean difference = - 18.46 mg/dL, 95% confidence interval [- 29.73, - 7.2], p = 0.001) with no heterogeneity (I² = 0%). The observed reduction in triglycerides (18.46 mg/dL) exceeds the reported minimal clinically important difference (MCID) threshold for triglycerides (i.e., 7.97 mg/dL), suggesting clinically meaningful improvements. TSA confirmed that sufficient evidence has been accumulated to support the effect of probiotics on triglycerides, with the cumulative Z-curve crossing the required information size of 313 participants. These findings suggest that probiotic supplementation could be a valuable adjunct therapy for managing lipid profiles in patients undergoing bariatric surgery. Future research should focus on optimizing probiotic interventions, including identifying the most effective strains, dosages, and duration of supplementation.

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减肥手术后益生菌对甘油三酯水平的影响：一项试验序列分析。

这项荟萃分析和试验序列分析（TSA）调查了补充益生菌对减肥手术后患者甘油三酯水平的影响。一项全面的文献检索确定了涉及411名参与者的7项随机对照试验。荟萃分析显示，益生菌补充剂显著降低了甘油三酯水平（平均差异= - 18.46 mg/dL， 95%可信区间[- 29.73,- 7.2],p = 0.001），无异质性（I2 = 0%）。观察到的甘油三酯降低（18.46 mg/dL）超过了报道的甘油三酯最小临床重要差异（MCID）阈值（即7.97 mg/dL），表明有临床意义的改善。TSA证实，已经积累了足够的证据来支持益生菌对甘油三酯的影响，累积的z曲线跨越了313名参与者所需的信息大小。这些发现表明，补充益生菌可能是一种有价值的辅助治疗，用于控制接受减肥手术的患者的脂质谱。未来的研究应侧重于优化益生菌干预措施，包括确定最有效的菌株、剂量和补充时间。

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来源期刊

Obesity Surgery 医学-外科

CiteScore

5.80

自引率

24.10%

发文量

567

审稿时长

3-6 weeks

期刊介绍： Obesity Surgery is the official journal of the International Federation for the Surgery of Obesity and metabolic disorders (IFSO). A journal for bariatric/metabolic surgeons, Obesity Surgery provides an international, interdisciplinary forum for communicating the latest research, surgical and laparoscopic techniques, for treatment of massive obesity and metabolic disorders. Topics covered include original research, clinical reports, current status, guidelines, historical notes, invited commentaries, letters to the editor, medicolegal issues, meeting abstracts, modern surgery/technical innovations, new concepts, reviews, scholarly presentations and opinions. Obesity Surgery benefits surgeons performing obesity/metabolic surgery, general surgeons and surgical residents, endoscopists, anesthetists, support staff, nurses, dietitians, psychiatrists, psychologists, plastic surgeons, internists including endocrinologists and diabetologists, nutritional scientists, and those dealing with eating disorders.