Improved synthesis and characterization of bile acid esters: Organogelation and supramolecular properties.

IF 2.1 4区 医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Steroids Pub Date : 2025-01-09 DOI:10.1016/j.steroids.2025.109560
Jair García-Méndez, Adolfo López-Torres, María A Fernández-Herrera
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Abstract

Bile acid esters and their derivatives hold significant interest due to their applications in fields such as supramolecular chemistry, biomedicine, and nanomaterials. This study revisits the synthesis and characterization of esters derived from cholic, deoxycholic, and lithocholic acids using short-chain alcohols in combination with microwave-assisted heating. The synthesized esters were analyzed for their potential as gel-forming agents, and their organogelation properties were evaluated. Microwave-assisted synthesis offers rapid and efficient esterification, leading to high yields with improved selectivity. The organogels were characterized through techniques such as differential scanning calorimetry (DSC) and scanning electron microscopy (SEM), revealing distinct structural and thermal properties. The study highlights the potential of these bile acid esters in materials science and supramolecular chemistry, contributing to the development of novel functional materials.

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胆汁酸酯的改进合成和表征:有机凝胶化和超分子性质。
胆汁酸酯及其衍生物由于在超分子化学、生物医学和纳米材料等领域的应用而引起了人们的极大兴趣。本研究回顾了利用短链醇与微波辅助加热相结合,从胆酸、脱氧胆酸和石胆酸中提取酯的合成和表征。分析了合成的酯类作为成胶剂的潜力,并评价了它们的有机凝胶化性能。微波辅助合成提供了快速和有效的酯化反应,导致高收率和提高选择性。通过差示扫描量热法(DSC)和扫描电镜(SEM)等技术对有机凝胶进行了表征,揭示了不同的结构和热性能。该研究强调了这些胆汁酸酯在材料科学和超分子化学方面的潜力,有助于开发新型功能材料。
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来源期刊
Steroids
Steroids 医学-内分泌学与代谢
CiteScore
5.10
自引率
3.70%
发文量
120
审稿时长
73 days
期刊介绍: STEROIDS is an international research journal devoted to studies on all chemical and biological aspects of steroidal moieties. The journal focuses on both experimental and theoretical studies on the biology, chemistry, biosynthesis, metabolism, molecular biology, physiology and pharmacology of steroids and other molecules that target or regulate steroid receptors. Manuscripts presenting clinical research related to steroids, steroid drug development, comparative endocrinology of steroid hormones, investigations on the mechanism of steroid action and steroid chemistry are all appropriate for submission for peer review. STEROIDS publishes both original research and timely reviews. For details concerning the preparation of manuscripts see Instructions to Authors, which is published in each issue of the journal.
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