Evaluating Graft Loss Risk in Living-Donor Kidney Transplants with Multiple Renal Arteries.

IF 1.1 4区医学 Q3 SURGERY Annals of Transplantation Pub Date : 2024-12-31 DOI:10.12659/AOT.946489

Kuniaki Inoue, Shunta Hori, Mitsuru Tomizawa, Tatsuo Yoneda, Yasushi Nakai, Makito Miyake, Nobumichi Tanaka, Kiyohide Fujimoto

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Abstract

BACKGROUND Despite its surgical complexity, kidney transplantation (KT) with multiple renal arteries (MRA) is comparable in performance to KT with a single renal artery (SRA). This study aimed to evaluate the effect of MRA and to investigate risk factors for graft loss in living-donor KT with MRA. MATERIAL AND METHODS This study included living-donor KT recipients who underwent KT in our hospital from February 2002 to March 2023. The primary outcome was whether MRA decreased the prognosis of transplanted kidneys. The secondary outcomes were the risk factors for graft loss in KT with MRA, such as recipients' characteristic. RESULTS Out of 197 recipients, 47 (23.8%) received kidneys with MRA. In inverse probability of treatment weighting, the risk of graft loss did not increase in KT with MRA, as compared to that in KT with SRA (hazard ratio [HR]: 1.46; 95% confidence interval [CI]: 0.68-3.14). MRA were associated with graft loss in ABO blood-incompatible KT (HR: 5.09, 95% CI: 1.75-14.7). CONCLUSIONS In ABO blood-incompatible KT, MRA can increase risk of graft loss.

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评估多肾动脉活体肾移植的移植物损失风险。

背景：尽管手术复杂，多肾动脉肾移植（KT）的表现与单肾动脉肾移植（SRA）相当。本研究旨在评估MRA的效果，并探讨MRA活体供体KT移植损失的危险因素。材料与方法本研究纳入2002年2月至2023年3月在我院行KT术的活体供体KT受者。主要观察结果是MRA是否降低了移植肾的预后。次要结局是MRA KT移植损失的危险因素，如受者的特征。结果197例受者中，47例（23.8%）接受了MRA肾。在治疗加权的逆概率中，与合并SRA的KT相比，合并MRA的KT的移植物损失风险没有增加(风险比[HR]: 1.46；95%可信区间[CI]: 0.68-3.14)。在ABO血型不相容的KT中，MRA与移植物损失相关（HR: 5.09, 95% CI: 1.75-14.7）。结论：在ABO血型不相容的KT中，MRA可增加移植物丢失的风险。

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来源期刊

Annals of Transplantation 医学-外科

CiteScore

2.50

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Annals of Transplantation is one of the fast-developing journals open to all scientists and fields of transplant medicine and related research. The journal is published quarterly and provides extensive coverage of the most important advances in transplantation. Using an electronic on-line submission and peer review tracking system, Annals of Transplantation is committed to rapid review and publication. The average time to first decision is around 3-4 weeks. Time to publication of accepted manuscripts continues to be shortened, with the Editorial team committed to a goal of 3 months from acceptance to publication. Expert reseachers and clinicians from around the world contribute original Articles, Review Papers, Case Reports and Special Reports in every pertinent specialty, providing a lot of arguments for discussion of exciting developments and controversies in the field.