Association between population viral load surrogate indicator and HIV transmission potential: a prospective cohort study in Xinjiang, China.

IF 3.5 2区医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH BMC Public Health Pub Date : 2025-01-11 DOI:10.1186/s12889-025-21278-6

Qian He, Yongkang Ni, Yuefei Li, Xiaoyuan Hu, Xiaomin Hu, Zhen Ni, Changyu Zeng, Aizimaiti Aikebaier, Bixin Xu, Mingjian Ni

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Abstract

Background: New indicators of potential human immunodeficiency virus (HIV) transmission are being actively explored. We aim to categorical testing of the viral load (VL) of persons living with HIV (PLWH) in order to explore new indicators to measure the intensity of the epidemic and the effectiveness of the response in the community.

Methods: A dynamic cohort study was conducted in Yining to monitor the VL of all persons living with HIV from 2017 to 2019. Different population VL (PVL) surrogate indicators were measured and the strength of the associations of different PVL surrogates with HIV incidence, antiretroviral therapy (ART) coverage, virus unsuppression, and viremia prevalence was assessed. PVL surrogate indicators were used to describe the current status of HIV transmission in different populations and communities.

Results: All PVL indicators decreased from 2017 to 2019 (P < 0.05). Arithmetic mean community viral load (CVL) (r = 1.000, P = 0.006) and geometric mean CVL (r = 1.000, P = 0.001) were positively associated with HIV incidence, ART coverage and viral unsuppression (P < 0.05). CVL was higher in the male, ≤ 25 years of age, primary school or below, other household registration, other medical insurance types, other source of sample, nonmarital and noncommercial heterosexual contact, and nonmarital and commercial heterosexual contact subgroups. Community-based cross-sectional analyses showed that CVL in community 10 was positively correlated with viral unsuppression rate and viremia prevalence but negatively correlated with ART coverage rate, suggesting that the community was a hotspot for HIV epidemics.

Conclusions: CVL can be used as an indicator for assessing HIV transmission and identifying high-risk populations and hotspot communities.

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中国新疆地区人群病毒载量替代指标与HIV传播潜力的关系：一项前瞻性队列研究

背景：人类免疫缺陷病毒（HIV）潜在传播的新指标正在被积极探索。我们的目标是对艾滋病毒感染者的病毒载量进行分类测试，以探索新的指标来衡量疫情的严重程度和社区应对措施的有效性。方法：在伊宁市开展动态队列研究，监测2017 - 2019年所有HIV感染者的VL。测量不同人群VL （PVL）替代指标，并评估不同PVL替代指标与HIV发病率、抗逆转录病毒治疗（ART）覆盖率、病毒不抑制和病毒血症患病率的相关性。使用PVL替代指标来描述不同人群和社区的HIV传播现状。结果：2017 - 2019年PVL指标均有所下降(P)。结论：CVL可作为评估HIV传播、识别高危人群和热点社区的指标。

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来源期刊

BMC Public Health 医学-公共卫生、环境卫生与职业卫生

CiteScore

6.50

自引率

4.40%

发文量

2108

审稿时长

1 months

期刊介绍： BMC Public Health is an open access, peer-reviewed journal that considers articles on the epidemiology of disease and the understanding of all aspects of public health. The journal has a special focus on the social determinants of health, the environmental, behavioral, and occupational correlates of health and disease, and the impact of health policies, practices and interventions on the community.