Oral Anticancer Therapies: Addressing Nonadherence in Patients With Breast Cancer

IF 2.5 3区医学 Q2 ONCOLOGY Clinical breast cancer Pub Date : 2024-12-17 DOI:10.1016/j.clbc.2024.12.011

M.E. Cazzaniga , J. Huober , A. Tamma , A. Emde , K. Thoele , J. O'Shaughnessy

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Abstract

This review aims to investigate the issue of treatment nonadherence and to present the available strategies to improve adherence to oral treatments in breast cancer. A literature search was conducted to contextualise the issue of nonadherence, investigate the reasons behind nonadherence, and demonstrate strategies to address treatment nonadherence in breast cancer. Findings indicate that adherence rates decrease while discontinuation rates increase with increasing lengths of breast cancer treatment course. Lack of adherence is proven to be detrimental to treatment outcomes. Patients struggle to adhere to treatment due to inadequate relationships with healthcare providers, lack of information, psychological distress, and side effects. Healthcare providers should evaluate patient's experience to provide the necessary support. Following this assessment, healthcare providers may recommend interventions addressing patient knowledge, psychological distress or side effects. Treatment adherence remains an issue for oral therapeutics in breast cancer. After patient assessment, healthcare providers can offer personalised strategies to improve treatment adherence. The most crucial interventions address patient knowledge, psychological distress, and side effects.

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口服抗癌疗法：解决乳腺癌患者的不依从性。

本综述旨在探讨治疗不依从性问题，并提出提高乳腺癌口服治疗依从性的可行策略。我们进行了一项文献检索，将不依从问题置于背景下，调查不依从背后的原因，并展示解决乳腺癌治疗不依从的策略。研究结果表明，随着乳腺癌治疗疗程的延长，依从率下降，而停药率上升。缺乏依从性已被证明对治疗结果有害。由于与医疗保健提供者的关系不充分，缺乏信息，心理困扰和副作用，患者难以坚持治疗。医疗保健提供者应评估患者的经验，以提供必要的支持。在此评估之后，医疗保健提供者可能会推荐针对患者知识、心理困扰或副作用的干预措施。治疗依从性仍然是乳腺癌口服治疗的一个问题。患者评估后，医疗保健提供者可以提供个性化的策略，以提高治疗依从性。最关键的干预措施涉及患者知识、心理困扰和副作用。

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来源期刊

Clinical breast cancer 医学-肿瘤学

CiteScore

5.40

自引率

3.20%

发文量

174

审稿时长

48 days

期刊介绍： Clinical Breast Cancer is a peer-reviewed bimonthly journal that publishes original articles describing various aspects of clinical and translational research of breast cancer. Clinical Breast Cancer is devoted to articles on detection, diagnosis, prevention, and treatment of breast cancer. The main emphasis is on recent scientific developments in all areas related to breast cancer. Specific areas of interest include clinical research reports from various therapeutic modalities, cancer genetics, drug sensitivity and resistance, novel imaging, tumor genomics, biomarkers, and chemoprevention strategies.