Inflammatory bowel disease increases the risk of pancreatitis: a two-sample bidirectional Mendelian randomization analysis.

IF 2.5 3区医学 Q2 GASTROENTEROLOGY & HEPATOLOGY BMC Gastroenterology Pub Date : 2025-01-11 DOI:10.1186/s12876-024-03571-7

Li-Hui Fang, Jia-Qi Zhang, Jin-Ke Huang, Xu-Dong Tang

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引用次数: 0

Abstract

Background: Previous studies have suggested an association between inflammatory bowel disease (IBD), and pancreatitis, including acute pancreatitis (AP) and chronic pancreatitis (CP). We aimed to examine the potential causal relationship between IBD and pancreatitis using the Mendelian randomization (MR) method.

Methods: We obtained data from genome-wide association studies (GWASs) in European individuals for IBD and its main subtypes, Crohn's disease (CD) and ulcerative colitis (UC) (31,665 IBD cases, 13,768 UC cases, 17,897 CD cases and 33,977 controls). Four independent summary statistics of pancreatitis from the the European Bioinformatics Institute (EMBL-EBI, 10,630 AP cases and 844,679 controls, 1,424 CP cases and 476,104 controls) and FinnGen Consortium (8,446 AP cases, 4,820 CP cases and 437,418 controls) were used for bidirectional MR analyses and sensitivity analysis. Finally, further meta-analysis was conducted on the MR results.

Results: Generally, IBD is associated with an increased risk of pancreatitis (IBD-AP, OR = 1.050, 95% CI 1.020-1.080, P = 7.20 × 10^-5; IBD-CP, OR = 1.050, 95% CI 1.010-1.090, P = 0.019). In addition, UC increased the risk of pancreatitis (UC-AP, OR = 1.050, 95% CI 1.020-1.070, P = 9.10 × 10^-5; UC-CP, OR = 1.090, 95% CI 1.040-1.140, P = 1.44 × 10^-4) and CD increased the risk of acute pancreatitis (OR = 1.040, 95% CI 1.020-1.060, P = 9.61 × 10^-5). However, no causal association was found between CD and the risk of chronic pancreatitis (P > 0.05). The reverse MR results showed that AP may be associated with a reduced risk of IBD and CD (AP-IBD, OR = 0.880, 95% CI 0.810-0.960, P = 0.003; AP-CD, OR = 0.830, 95% CI 0.730-0.940, P = 0.003). However, there is no causal relationship between AP and the risk of UC, and there is no causal relationship between CP and the risk of IBD and its subtypes(P > 0.05).

Conclusion: In conclusion, based on MR analysis and meta-analysis, our results showed a positive causal effect of IBD on pancreatitis, and subgroup analyses showed that UC and CD may promote the development of acute pancreatitis, whereas UC may promote the development of chronic pancreatitis. Reverse MR analysis suggests that AP may have a potential protective effect on IBD and CD.

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炎症性肠病增加胰腺炎的风险：一项双样本双向孟德尔随机分析

背景：先前的研究表明炎症性肠病（IBD）和胰腺炎（包括急性胰腺炎（AP）和慢性胰腺炎（CP））之间存在关联。我们旨在使用孟德尔随机化（MR）方法检查IBD和胰腺炎之间的潜在因果关系。方法：我们获得了欧洲IBD及其主要亚型克罗恩病（CD）和溃疡性结肠炎（UC）个体的全基因组关联研究（GWASs）数据（31,665例IBD病例，13,768例UC病例，17,897例CD病例和33,977例对照）。使用来自欧洲生物信息学研究所（EMBL-EBI, 10,630例AP病例和844,679例对照，1,424例CP病例和476,104例对照）和FinnGen联盟（8,446例AP病例，4,820例CP病例和437,418例对照）的四个独立胰腺炎汇总统计数据进行双向MR分析和敏感性分析。最后，对MR结果进行进一步的meta分析。结果：一般来说，IBD与胰腺炎风险增加相关(IBD- ap, OR = 1.050, 95% CI 1.020-1.080, P = 7.20 × 10-5；IBD-CP或= 1.050,95% CI 1.010 - -1.090, P = 0.019)。此外，UC增加了胰腺炎的风险(UC- ap, OR = 1.050, 95% CI 1.020-1.070, P = 9.10 × 10-5；UC-CP, OR = 1.090, 95% CI 1.040-1.140, P = 1.44 × 10-4)和CD增加急性胰腺炎的风险（OR = 1.040, 95% CI 1.020-1.060, P = 9.61 × 10-5）。然而，没有发现CD与慢性胰腺炎风险之间的因果关系（P < 0.05）。相反的MR结果显示，AP可能与IBD和CD的风险降低相关(AP-IBD, OR = 0.880, 95% CI 0.810-0.960, P = 0.003；AP-CD或= 0.830,95% CI 0.730 - -0.940, P = 0.003)。然而，AP与UC风险之间没有因果关系，CP与IBD及其亚型风险之间没有因果关系（P < 0.05）。结论：综上所述，基于MR分析和meta分析，我们的研究结果显示IBD与胰腺炎存在正因果关系，亚组分析显示UC和CD可能促进急性胰腺炎的发展，而UC可能促进慢性胰腺炎的发展。反向MR分析表明，AP可能对IBD和CD有潜在的保护作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

BMC Gastroenterology 医学-胃肠肝病学

CiteScore

4.20

自引率

0.00%

发文量

465

审稿时长

6 months

期刊介绍： BMC Gastroenterology is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of gastrointestinal and hepatobiliary disorders, as well as related molecular genetics, pathophysiology, and epidemiology.