Recent advances in research on common targets of neurological and sex hormonal influences on asthma

IF 4.6 2区医学 Q2 ALLERGY Clinical and Translational Allergy Pub Date : 2025-01-12 DOI:10.1002/clt2.70022

Wenting Zhou, Huan Chen, Xinyu Chen, Jing Gao, Wenting Ji

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Abstract

Background

Asthma is currently one of the most common of respiratory diseases, severely affecting the lives of patients. With the in-depth study of the role of the nervous system and sex hormones on the development of asthma, it has been found that the nervous system and sex hormones are related to each other in the pathway of asthma.

Objective

To investigate the effects of sex hormones and the nervous system on the development of asthma.

Methods

In this review, we searched for a large number of relevant literature to elucidate the unique mechanisms of sex hormones and the nervous system on asthma development, and summarized several common targets in the pathways of sex hormones and the nervous system on asthma.

Conclusion

We summarize several common important targets in the pathways of action of sex hormones and the nervous system in asthma, provide new directions and ideas for asthma treatment, and discuss current therapeutic limitations and future possibilities. Finally, the article predicts future applications of several important targets in asthma therapy.

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神经和性激素对哮喘共同作用靶点的研究进展。

背景：哮喘是目前最常见的呼吸系统疾病之一，严重影响患者的生活。随着神经系统和性激素对哮喘发病作用的深入研究，人们发现神经系统和性激素在哮喘的发病途径中相互关联：研究性激素和神经系统对哮喘发病的影响：在这篇综述中，我们检索了大量相关文献，阐明了性激素和神经系统对哮喘发病的独特机制，并总结了性激素和神经系统对哮喘发病途径中的几个共同靶点：我们总结了性激素和神经系统作用于哮喘的途径中几个常见的重要靶点，为哮喘的治疗提供了新的方向和思路，并讨论了目前治疗的局限性和未来的可能性。最后，文章预测了几个重要靶点在哮喘治疗中的未来应用。

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来源期刊

Clinical and Translational Allergy Immunology and Microbiology-Immunology

CiteScore

7.50

自引率

4.50%

发文量

117

审稿时长

12 weeks

期刊介绍： Clinical and Translational Allergy, one of several journals in the portfolio of the European Academy of Allergy and Clinical Immunology, provides a platform for the dissemination of allergy research and reviews, as well as EAACI position papers, task force reports and guidelines, amongst an international scientific audience. Clinical and Translational Allergy accepts clinical and translational research in the following areas and other related topics: asthma, rhinitis, rhinosinusitis, drug hypersensitivity, allergic conjunctivitis, allergic skin diseases, atopic eczema, urticaria, angioedema, venom hypersensitivity, anaphylaxis, food allergy, immunotherapy, immune modulators and biologics, animal models of allergic disease, immune mechanisms, or any other topic related to allergic disease.