Daughters of PCOS mothers and AMH plasma concentrations in pre-puberty and puberty: A meta-analysis.

IF 2.2 3区医学 Q2 OBSTETRICS & GYNECOLOGY Early human development Pub Date : 2025-01-06 DOI:10.1016/j.earlhumdev.2025.106194

Polina Pavli, Theodoros Kalampokas, Makarios Eleftheriades, Irene Lambrinoudaki, Nikolaos F Vlahos, George Valsamakis

{"title":"Daughters of PCOS mothers and AMH plasma concentrations in pre-puberty and puberty: A meta-analysis.","authors":"Polina Pavli, Theodoros Kalampokas, Makarios Eleftheriades, Irene Lambrinoudaki, Nikolaos F Vlahos, George Valsamakis","doi":"10.1016/j.earlhumdev.2025.106194","DOIUrl":null,"url":null,"abstract":"Purpose: to compare the Anti-Müllerian hormone (AMH) plasma concentrations of pre-pubertal and pubertal daughters born to polycystic ovary syndrome (PCOS) mothers to daughters born to control mothers and to investigate their alterations during pre-puberty and all stages of puberty.Methods: We critically investigated and meta-analyzed observational studies, which compared the plasma concentrations of AMH in pre-pubertal and pubertal daughters of PCOS pregnancies. A search of the literature was completed till the end of June of 2024 in the PubMed, Scopus, and Medline for the eligible studies. The meta-analysis followed the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA). The primary outcome included AMH plasma concentrations.Results: Our search yielded 961 potentially eligible studies, 5 of which were finally studied. Pre-pubertal female offsprings of PCOS mothers present higher plasma concentrations of AMH, with the pooled mean difference 10.08, while also pubertal daughters of PCOS mothers present higher plasma concentrations of AMH, with the pooled mean difference 15.79.Conclusion: Pre-pubertal and pubertal female offsprings of PCOS mothers show higher AMH plasma concentrations, when compared to daughters of healthy mothers without PCOS. The main pathophysiological pathways of these findings seem to be hyperandrogenism, hyperinsulinemia, and also genetic, epigenetic and intrauterine factors.","PeriodicalId":11435,"journal":{"name":"Early human development","volume":"201 ","pages":"106194"},"PeriodicalIF":2.2000,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Early human development","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.earlhumdev.2025.106194","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"OBSTETRICS & GYNECOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Purpose: to compare the Anti-Müllerian hormone (AMH) plasma concentrations of pre-pubertal and pubertal daughters born to polycystic ovary syndrome (PCOS) mothers to daughters born to control mothers and to investigate their alterations during pre-puberty and all stages of puberty.

Methods: We critically investigated and meta-analyzed observational studies, which compared the plasma concentrations of AMH in pre-pubertal and pubertal daughters of PCOS pregnancies. A search of the literature was completed till the end of June of 2024 in the PubMed, Scopus, and Medline for the eligible studies. The meta-analysis followed the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA). The primary outcome included AMH plasma concentrations.

Results: Our search yielded 961 potentially eligible studies, 5 of which were finally studied. Pre-pubertal female offsprings of PCOS mothers present higher plasma concentrations of AMH, with the pooled mean difference 10.08, while also pubertal daughters of PCOS mothers present higher plasma concentrations of AMH, with the pooled mean difference 15.79.

Conclusion: Pre-pubertal and pubertal female offsprings of PCOS mothers show higher AMH plasma concentrations, when compared to daughters of healthy mothers without PCOS. The main pathophysiological pathways of these findings seem to be hyperandrogenism, hyperinsulinemia, and also genetic, epigenetic and intrauterine factors.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

目的：比较多囊卵巢综合征（PCOS）母亲所生青春期前和青春期女儿与对照组母亲所生女儿的抗缪勒氏管激素（AMH）血浆浓度，并研究其在青春期前和青春期各阶段的变化：我们对观察性研究进行了批判性调查和荟萃分析，这些研究比较了多囊卵巢综合征妊娠的青春期前女儿和青春期女儿的血浆AMH浓度。截至 2024 年 6 月底，我们在 PubMed、Scopus 和 Medline 上对符合条件的研究进行了文献检索。荟萃分析遵循了系统综述和荟萃分析的首选报告项目（PRISMA）。主要结果包括 AMH 血浆浓度：我们的搜索结果显示，有 961 项研究可能符合条件，其中 5 项最终得到了研究结果。多囊卵巢综合征母亲的青春期前女儿血浆中的AMH浓度较高，汇集平均差为10.08；多囊卵巢综合征母亲的青春期女儿血浆中的AMH浓度也较高，汇集平均差为15.79：多囊卵巢综合症母亲的青春期前和青春期女性后代与无多囊卵巢综合症的健康母亲的女儿相比，AMH血浆浓度更高。这些发现的主要病理生理途径似乎是高雄激素、高胰岛素血症，以及遗传、表观遗传和宫内因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Early human development 医学-妇产科学

CiteScore

4.40

自引率

4.00%

发文量

100

审稿时长

46 days

期刊介绍： Established as an authoritative, highly cited voice on early human development, Early Human Development provides a unique opportunity for researchers and clinicians to bridge the communication gap between disciplines. Creating a forum for the productive exchange of ideas concerning early human growth and development, the journal publishes original research and clinical papers with particular emphasis on the continuum between fetal life and the perinatal period; aspects of postnatal growth influenced by early events; and the safeguarding of the quality of human survival. The first comprehensive and interdisciplinary journal in this area of growing importance, Early Human Development offers pertinent contributions to the following subject areas: Fetology; perinatology; pediatrics; growth and development; obstetrics; reproduction and fertility; epidemiology; behavioural sciences; nutrition and metabolism; teratology; neurology; brain biology; developmental psychology and screening.