Optimizing pre-eclampsia prevention: Embracing low-dose calcium in sub-Saharan Africa

Abstract

Pre-eclampsia remains a significant health challenge in sub-Saharan Africa, contributing substantially to maternal and neonatal mortality rates. This paper explores the potential of low-dose calcium supplementation as an alternative strategy to the conventional high-dose regimen in preventing pre-eclampsia. A consistent association between low serum calcium levels and an increased risk of pre-eclampsia is established based on studies spanning Ghana, Nigeria, and Ethiopia. The challenges associated with implementing high-dose calcium supplementation, including cost, logistics, limited information, and adherence issues, underscore the need for a paradigm shift. The evidence presented advocates for integrating low-dose calcium supplementation into sub-Saharan African prenatal care programs. The paper emphasizes the role of healthcare providers in educating women about the benefits and safety of low-dose calcium supplements. Future research and implementation initiatives are urged to refine and tailor these approaches to the region's diverse needs, advancing the collective goal of enhancing maternal and newborn health. This exploration of creative and context-specific solutions underscores the potential of low-dose calcium to significantly contribute to reducing the prevalence of hypertensive disorders in pregnancy, particularly pre-eclampsia, ultimately contributing to healthier and thriving communities in sub-Saharan Africa.