Effects of home-based interventions on cognitive performance in patients with dementia: A systematic review and meta-analysis.

IF 3.4 3区医学 Q2 NEUROSCIENCES Journal of Alzheimer's Disease Pub Date : 2025-01-12 DOI:10.1177/13872877241301456

Xichao Ma, Yu Wang, Xinxin Chen, Shijie Zhu, Yang Lin, Shaxin Liu, Yonghong Yang

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Abstract

Background: With increasing age, dementia is a common disease in the elderly population，especially Alzheimer's disease. Owing to the nature of the disease, the function of patients deteriorates, which places a heavy burden on the country and family. Home-based training programs have been shown to improve cognitive function in patients with dementia.

Objective: To examine the effects and methods of home-based interventions on the cognitive performance of patients with dementia.

Methods: This systematic review and meta-analysis was conducted on the basis of the PRISMA statement. This protocol was registered in advance at PROSPERO (CRD42021277269). Six English electronic databases, including PubMed, EMBASE, the Cochrane Library, Web of Science, SCOPUS, and OTseeker, were searched and updated to January 31, 2024. Two researchers independently completed the literature retrieval and data extraction. RevMan 5.3 software was used to analyze the data. The standardized mean difference and the 95% confidence interval were used for statistical analysis. Subgroup analyses were performed by assessment tools, intervention duration and intervention methods.

Results: Twenty randomized controlled trials with 3543 participants were included in the qualitative synthesis, and 17 studies were included in the meta-analysis. Compared with the control intervention, the home-based intervention significantly improved cognitive performance (SMD = 0.45; 95% CI = [0.17, 0.74]; p = 0.002).

Conclusions: Moderate to high evidence shows that home-based interventions significantly improve the cognitive performance of patients with dementia, especially their comprehensive cognitive function.

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家庭干预对痴呆患者认知表现的影响：系统回顾和荟萃分析。

背景：随着年龄的增长，痴呆是老年人群的常见病，尤其是阿尔茨海默病。由于这种疾病的性质，病人的功能恶化，给国家和家庭带来沉重的负担。以家庭为基础的训练项目已被证明可以改善痴呆症患者的认知功能。目的：探讨家庭干预对痴呆患者认知能力的影响及方法。方法：以PRISMA声明为基础进行系统评价和meta分析。本协议已在PROSPERO （CRD42021277269）提前注册。检索了PubMed、EMBASE、Cochrane Library、Web of Science、SCOPUS和OTseeker 6个英文电子数据库，并将其更新至2024年1月31日。两位研究者独立完成文献检索和数据提取。采用RevMan 5.3软件对数据进行分析。采用标准化均差和95%置信区间进行统计分析。按评估工具、干预时间和干预方式进行亚组分析。结果：定性综合纳入20项随机对照试验，共3543名受试者，meta分析纳入17项研究。与对照组干预相比，以家庭为基础的干预显著改善了认知表现(SMD = 0.45；95% ci = [0.17, 0.74]；p = 0.002)。结论：中高证据表明，家庭干预可显著改善痴呆患者的认知表现，尤其是其综合认知功能。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Alzheimer's Disease 医学-神经科学

CiteScore

6.40

自引率

7.50%

发文量

1327

审稿时长

2 months

期刊介绍： The Journal of Alzheimer''s Disease (JAD) is an international multidisciplinary journal to facilitate progress in understanding the etiology, pathogenesis, epidemiology, genetics, behavior, treatment and psychology of Alzheimer''s disease. The journal publishes research reports, reviews, short communications, hypotheses, ethics reviews, book reviews, and letters-to-the-editor. The journal is dedicated to providing an open forum for original research that will expedite our fundamental understanding of Alzheimer''s disease.