Elevating Dermatology Beyond Aesthetics: Perinatal-Derived Advancements for Rejuvenation, Alopecia Strategies, Scar Therapies, and Progressive Wound Healing.

IF 4.5 3区 医学 Q2 CELL & TISSUE ENGINEERING Stem Cell Reviews and Reports Pub Date : 2025-01-13 DOI:10.1007/s12015-024-10835-y
Mohammad Amin Khalilzad, Javad Mohammadi, Soumayeh Amirsaadat, Sajad Najafi, Sona Zare, Mohammad Ali Nilforoushzadeh, Mitra Khalilzad, Ayoub Khaghani, Mohammad Reza Fayyazi Soltankouhi, Alireza Hajimohammad
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Abstract

Dermatologists have been interested in recent advancements in regenerative therapy. Current research is actively investigating the possibility of placental tissue derivatives to decelerate the skin aging process, enhance skin regeneration, reduce scarring, and prevent hair loss. Amniotic membranes (AM) play a crucial role in regenerative medicine as they serve as a suitable means of transporting stem cells, growth hormones, cytokines, and other essential compounds. Regulating an intricate network of biological processes improves the development and repair of tissues. Studies done by dermatologists indicate that several compounds found in the decidua, umbilical cord, and amniotic membrane have the potential to be used for regeneration. Examples include mesenchymal stem cells, growth factors, and immunomodulatory pharmaceuticals. Due to research and technological developments, scientists may use placental sections to facilitate skin regeneration, minimize scarring, and expedite wound healing. This study examines the current state of dermatological therapy, with a focus on using derivatives obtained from fetal tissue as the basis. The critical areas of study focus on this strategy are the potential benefits, growth opportunities, and recovery rates. Based on a thorough examination of the available literature and clinical data, we want to make definitive conclusions on the possible influence of fetal tissue derivatives in dermatological therapy.

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提升皮肤病学超越美学:围产期再生、脱发策略、疤痕治疗和渐进式伤口愈合的进展。
皮肤科医生对再生疗法的最新进展很感兴趣。目前的研究正在积极探索胎盘组织衍生物在减缓皮肤老化过程、促进皮肤再生、减少疤痕和防止脱发方面的可能性。羊膜在再生医学中起着至关重要的作用,因为它们是运输干细胞、生长激素、细胞因子和其他必需化合物的合适途径。调节复杂的生物过程网络可以促进组织的发育和修复。皮肤科医生的研究表明,在蜕膜、脐带和羊膜中发现的几种化合物具有用于再生的潜力。例子包括间充质干细胞、生长因子和免疫调节药物。由于研究和技术的发展,科学家可能会使用胎盘切片来促进皮肤再生,最大限度地减少疤痕,并加速伤口愈合。本研究考察了皮肤科治疗的现状,重点是使用从胎儿组织中获得的衍生物作为基础。研究这一策略的关键领域是潜在收益、增长机会和回收率。基于对现有文献和临床数据的彻底检查,我们希望对胎儿组织衍生物在皮肤病治疗中的可能影响做出明确的结论。
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来源期刊
Stem Cell Reviews and Reports
Stem Cell Reviews and Reports 医学-细胞生物学
CiteScore
9.30
自引率
4.20%
发文量
0
审稿时长
3 months
期刊介绍: The purpose of Stem Cell Reviews and Reports is to cover contemporary and emerging areas in stem cell research and regenerative medicine. The journal will consider for publication: i) solicited or unsolicited reviews of topical areas of stem cell biology that highlight, critique and synthesize recent important findings in the field. ii) full length and short reports presenting original experimental work. iii) translational stem cell studies describing results of clinical trials using stem cells as therapeutics. iv) papers focused on diseases of stem cells. v) hypothesis and commentary articles as opinion-based pieces in which authors can propose a new theory, interpretation of a controversial area in stem cell biology, or a stem cell biology question or paradigm. These articles contain more speculation than reviews, but they should be based on solid rationale. vi) protocols as peer-reviewed procedures that provide step-by-step descriptions, outlined in sufficient detail, so that both experts and novices can apply them to their own research. vii) letters to the editor and correspondence. In order to facilitate this exchange of scientific information and exciting novel ideas, the journal has created five thematic sections, focusing on: i) the role of adult stem cells in tissue regeneration; ii) progress in research on induced pluripotent stem cells, embryonic stem cells and mechanism governing embryogenesis and tissue development; iii) the role of microenvironment and extracellular microvesicles in directing the fate of stem cells; iv) mechanisms of stem cell trafficking, stem cell mobilization and homing with special emphasis on hematopoiesis; v) the role of stem cells in aging processes and cancerogenesis.
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