Serologic detection of regenerating protein I alpha by time-resolved fluoroimmunoassay and its clinical value in gastric cancer.

Laboratory medicine Pub Date : 2025-01-11 DOI:10.1093/labmed/lmae106

Zhongyi Xiang, Xiaoyan Wang, Akao Zhu, Xindong Chen, Yuan Qin, Xiumei Zhou, Xueqin Zhao, Yigang Wang, Biao Huang, Hongming Fang, Pengfei Liu

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Abstract

Background: Regenerating protein I alpha (REG Iα) plays a key role in the progression of gastric cancer (GC). However, the clinical application value of serum REG Iα in GC remains largely unknown.

Methods: Serum REG Iα levels were analyzed through time-resolved fluoroimmunoassay (TRFIA) in healthy controls (HCs) and patients with benign gastric disease (BGD) and GC.

Results: The REG Iα levels of patients with GC were significantly higher than those of HCs and patients with BGD (P < .0001). The REG Iα levels were higher in patients with GC with poor pathological differentiation type; tumor, node, and metastasis stages III-IV; deep tumor invasion (T3-T4); and distant metastasis (P < .05). The diagnostic efficiency of the combined REG Iα, carcinoembryonic antigen (CEA), and carbohydrate antigen 19-9 (CA19-9) tests improved compared with that of the single-indicator test for the diagnosis of patients with GC.

Conclusion: REG Iα-TRFIA may facilitate the ancillary diagnosis of GC and have a monitoring role for further progression of GC. It can also help elucidate the possible diagnostic role of serum REG Iα as a noninvasive tool.

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用时间分辨荧光免疫测定法检测再生蛋白 I alpha 的血清学特性及其在胃癌中的临床价值。

背景：再生蛋白Iα (REG Iα)在胃癌（GC）的进展中起关键作用。然而，血清REG Iα在胃癌中的临床应用价值尚不清楚。方法：采用时间分辨荧光免疫法（TRFIA）分析健康对照（hc）、良性胃病（BGD）和胃癌患者血清REG Iα水平。结果：GC患者的REG Iα水平显著高于hcc和BGD患者（P < 0.0001）。病理分型差的胃癌患者REG Iα水平较高；III-IV期肿瘤、淋巴结和转移；深部肿瘤侵袭（T3-T4）；远处转移（P < 0.05）。REG Iα、癌胚抗原（CEA）、碳水化合物抗原19-9 （CA19-9）联合检测对胃癌的诊断效率较单指标检测提高。结论：REG Iα-TRFIA有助于胃癌的辅助诊断，对胃癌的进一步发展具有监测作用。这也有助于阐明血清REG Iα作为一种无创诊断工具的可能作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Laboratory medicine

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