{"title":"Advances in the Design of Photoactivatable Metallodrugs: Excited State Metallomics","authors":"Huayun Shi, Rafael C. Marchi, Peter J. Sadler","doi":"10.1002/anie.202423335","DOIUrl":null,"url":null,"abstract":"Fasten your seat belt! Choose lightning-speed, photoactivated journeys for complexes by selecting the metal, its oxidation state, ligands and geometry. Track complexes through excited singlet (S) states, intersystem crossing (ISC) to triplet (T) states, energy/charge-transfer, luminescence, ligand substitutions and redox reactions. Pathways to novel drugs with new mechanisms of action. Unravelling excited metallomics on the way is challenging.","PeriodicalId":125,"journal":{"name":"Angewandte Chemie International Edition","volume":"89 1","pages":""},"PeriodicalIF":16.1000,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Angewandte Chemie International Edition","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1002/anie.202423335","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
Fasten your seat belt! Choose lightning-speed, photoactivated journeys for complexes by selecting the metal, its oxidation state, ligands and geometry. Track complexes through excited singlet (S) states, intersystem crossing (ISC) to triplet (T) states, energy/charge-transfer, luminescence, ligand substitutions and redox reactions. Pathways to novel drugs with new mechanisms of action. Unravelling excited metallomics on the way is challenging.
期刊介绍：
Angewandte Chemie, a journal of the German Chemical Society (GDCh), maintains a leading position among scholarly journals in general chemistry with an impressive Impact Factor of 16.6 (2022 Journal Citation Reports, Clarivate, 2023). Published weekly in a reader-friendly format, it features new articles almost every day. Established in 1887, Angewandte Chemie is a prominent chemistry journal, offering a dynamic blend of Review-type articles, Highlights, Communications, and Research Articles on a weekly basis, making it unique in the field.
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