Cognitive aging outcomes are related to both tau pathology and maintenance of cingulate cortex structure

IF 11.1 1区医学 Q1 CLINICAL NEUROLOGY Alzheimer's & Dementia Pub Date : 2025-01-14 DOI:10.1002/alz.14515

Stefania Pezzoli, Joseph Giorgio, Xi Chen, Tyler J. Ward, Theresa M. Harrison, William J. Jagust

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Abstract

INTRODUCTION

Successful cognitive aging is related to both maintaining brain structure and avoiding Alzheimer's disease (AD) pathology, but how these factors interplay is unclear.

METHODS

A total of 109 cognitively normal older adults (70+ years old) underwent amyloid beta (Aβ) and tau positron emission tomography (PET) imaging, structural magnetic resonance imaging (MRI), and cognitive testing. Cognitive aging was quantified using the cognitive age gap (CAG), subtracting chronological age from predicted cognitive age.

RESULTS

Lower CAG (younger cognitive age) was related to slower decline in episodic memory, multi-domain cognition, and atrophy of the midcingulate cortex (MCC). Lower entorhinal cortical tau was linked to slower decline in episodic memory, multi-domain cognition, and hippocampal atrophy.

DISCUSSION

These results suggest that aging outcomes may be influenced by two independent pathways: one associated with tau accumulation, affecting primarily memory and hippocampal atrophy, and another involving tau-independent structural preservation of the MCC, benefiting multi-domain cognition over time.

Highlights

Younger cognitive age (lower cognitive age gap [CAG]) is related to slower cognitive decline.
Lower CAG is linked to slower midcingulate cortex (MCC) atrophy.
Reduced tau in the entorhinal cortex is related to less hippocampal atrophy and cognitive decline.
Structural preservation of the MCC benefits multi-domain cognition over time.
Two independent pathways influence cognitive aging: tau accumulation and MCC preservation.

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认知老化结果与tau蛋白病理和扣带皮层结构的维持有关

成功的认知衰老与维持大脑结构和避免阿尔茨海默病（AD）病理有关，但这些因素如何相互作用尚不清楚。

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来源期刊

Alzheimer's & Dementia 医学-临床神经学

CiteScore

14.50

自引率

5.00%

发文量

299

审稿时长

3 months

期刊介绍： Alzheimer's & Dementia is a peer-reviewed journal that aims to bridge knowledge gaps in dementia research by covering the entire spectrum, from basic science to clinical trials to social and behavioral investigations. It provides a platform for rapid communication of new findings and ideas, optimal translation of research into practical applications, increasing knowledge across diverse disciplines for early detection, diagnosis, and intervention, and identifying promising new research directions. In July 2008, Alzheimer's & Dementia was accepted for indexing by MEDLINE, recognizing its scientific merit and contribution to Alzheimer's research.