Greta Utecht-Jarzyńska, Szymon Jarzyński and Marcin Jasiński
{"title":"Trapping in situ generated CF3-nitrile imines with maleimides under solvent-free mechanochemical conditions†","authors":"Greta Utecht-Jarzyńska, Szymon Jarzyński and Marcin Jasiński","doi":"10.1039/D4MR00075G","DOIUrl":null,"url":null,"abstract":"<p >A series of trifluoromethylated pyrrolo[3,4-<em>c</em>]pyrazoles was obtained <em>via</em> mechanochemical (3 + 2)-cycloaddition of <em>in situ</em> generated trifluoroacetonitrile imines with maleimide and its <em>N</em>-aliphatic/aromatic analogues. The presented work demonstrated that the aforementioned 1,3-dipoles can be efficiently trapped with electron-deficient dipolarophiles under solvent-free ball-milling conditions.</p>","PeriodicalId":101140,"journal":{"name":"RSC Mechanochemistry","volume":" 1","pages":" 79-82"},"PeriodicalIF":0.0000,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/mr/d4mr00075g?page=search","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"RSC Mechanochemistry","FirstCategoryId":"1085","ListUrlMain":"https://pubs.rsc.org/en/content/articlelanding/2025/mr/d4mr00075g","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
A series of trifluoromethylated pyrrolo[3,4-c]pyrazoles was obtained via mechanochemical (3 + 2)-cycloaddition of in situ generated trifluoroacetonitrile imines with maleimide and its N-aliphatic/aromatic analogues. The presented work demonstrated that the aforementioned 1,3-dipoles can be efficiently trapped with electron-deficient dipolarophiles under solvent-free ball-milling conditions.
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