Manganese carbonyl-encapsulated Fe-MOFs as a H2O2-responsive CO gas nanogenerator for synergistic gas/chemodynamic therapy†

IF 2.5 3区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY New Journal of Chemistry Pub Date : 2024-12-09 DOI:10.1039/D4NJ05085A

Fengqin Wang, Jian An, Shiyue Zhang, Jingjing Ma, Xufeng Liang, Jianxia Zhang, Jia Pu, Yujia Meng, Yiqiao Bai, Wenqiang Yu, Yunhan Gao, Yingfang Jiang, Tingting Chen, Yong Yao and Yang Wang

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Abstract

The combination of chemodynamic therapy (CDT) and gas therapy holds significant promise for tumor treatment. In this study, we successfully synthesized an intelligent H₂O₂-responsive Fe-MOF nanotherapeutic agent, integrated with glucose oxidase (GOx) and manganese carbonyl (MnCO), to achieve synergistic cancer gas/CDT. Upon endocytosis by tumor cells, the nanotherapeutic agent catalyzes the conversion of endogenous glucose into gluconic acid and H₂O₂, which facilitates the release of CO gas and disrupts the energy supply. Subsequently, a Fenton reaction occurs between Fe-MOFs and intracellular H₂O₂, generating highly toxic hydroxyl radicals (˙OH) for CDT. Therefore, the engineered nanotherapeutic agent demonstrates a synergistic efficacy through CO gas therapy, reactive oxygen species (ROS)-mediated CDT, and energy starvation, effectively suppressing tumor growth.

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羰基锰包封的fe - mof作为h2o2响应的CO气体纳米发生器用于协同气体/化学动力学治疗

化学动力疗法（CDT）和气体疗法的结合在肿瘤治疗中具有重要的前景。在本研究中，我们成功合成了一种智能h2o2响应的Fe-MOF纳米治疗剂，该治疗剂与葡萄糖氧化酶（GOx）和羰基锰（MnCO）结合，实现了癌症气体/CDT的协同作用。肿瘤细胞内吞后，纳米治疗剂催化内源性葡萄糖转化为葡萄糖酸和H2O2，促进CO气体的释放，破坏能量供应。随后，fe - mof与细胞内H2O2发生芬顿反应，生成CDT的高毒性羟基自由基（˙OH）。因此，该工程纳米治疗剂通过CO气体治疗、活性氧（ROS）介导的CDT和能量饥饿表现出协同效应，有效抑制肿瘤生长。

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