{"title":"Identification of a Bmh in a Chinese Individual.","authors":"Qing Li, Guojin Ou","doi":"10.7754/Clin.Lab.2024.240744","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>The Bombay and para-Bombay blood groups are rare blood types that are significant to clinical blood transfusions. Accurate para-Bombay blood group identification is important for the safety of transfusions.</p><p><strong>Methods: </strong>Serological and molecular biology methods were used to detect one case of ABO blood type. Genotypes of the para-Bombay blood group in the Chinese population were searched and summarized, and the safety of blood transfusion for this group was discussed.</p><p><strong>Results: </strong>The ABO genotype of the case was B101/O01 and the FUT1 gene haplotype was c.649T and 881_882 delTT, while the phenotypes were Bmh, h2/h649, Le(a-b-), and Se357/Se357,716.</p><p><strong>Conclusions: </strong>The h649/h2 FUT1 genotype is newly discovered and is responsible for the para-Bombay blood group in the Chinese population. Accurate identification of this blood group using serology and molecular methods is significant to ensure the safety of blood transfusions.</p>","PeriodicalId":10384,"journal":{"name":"Clinical laboratory","volume":"71 1","pages":""},"PeriodicalIF":0.7000,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical laboratory","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.7754/Clin.Lab.2024.240744","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"MEDICAL LABORATORY TECHNOLOGY","Score":null,"Total":0}
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Abstract
Background: The Bombay and para-Bombay blood groups are rare blood types that are significant to clinical blood transfusions. Accurate para-Bombay blood group identification is important for the safety of transfusions.
Methods: Serological and molecular biology methods were used to detect one case of ABO blood type. Genotypes of the para-Bombay blood group in the Chinese population were searched and summarized, and the safety of blood transfusion for this group was discussed.
Results: The ABO genotype of the case was B101/O01 and the FUT1 gene haplotype was c.649T and 881_882 delTT, while the phenotypes were Bmh, h2/h649, Le(a-b-), and Se357/Se357,716.
Conclusions: The h649/h2 FUT1 genotype is newly discovered and is responsible for the para-Bombay blood group in the Chinese population. Accurate identification of this blood group using serology and molecular methods is significant to ensure the safety of blood transfusions.
期刊介绍：
Clinical Laboratory is an international fully peer-reviewed journal covering all aspects of laboratory medicine and transfusion medicine. In addition to transfusion medicine topics Clinical Laboratory represents submissions concerning tissue transplantation and hematopoietic, cellular and gene therapies. The journal publishes original articles, review articles, posters, short reports, case studies and letters to the editor dealing with 1) the scientific background, implementation and diagnostic significance of laboratory methods employed in hospitals, blood banks and physicians'' offices and with 2) scientific, administrative and clinical aspects of transfusion medicine and 3) in addition to transfusion medicine topics Clinical Laboratory represents submissions concerning tissue transplantation and hematopoietic, cellular and gene therapies.
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