Influenza A virus in dairy cattle: infection biology and potential mammary gland-targeted vaccines.

IF 6.9 1区 医学 Q1 IMMUNOLOGY NPJ Vaccines Pub Date : 2025-01-14 DOI:10.1038/s41541-025-01063-7
Rodrigo Prado Martins, Daniel Marc, Pierre Germon, Sascha Trapp, Ignacio Caballero-Posadas
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Abstract

Influenza, a major "One Health" threat, has gained heightened attention following recent reports of highly pathogenic avian influenza in dairy cattle and cow-to-human transmission in the USA. This review explores general aspects of influenza A virus (IAV) biology, its interactions with mammalian hosts, and discusses the key considerations for developing vaccines to prevent or curtail IAV infection in the bovine mammary gland and its spread through milk.

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奶牛甲型流感病毒:感染生物学和潜在的乳腺靶向疫苗。
流感是“同一个健康”的主要威胁,最近在美国报道了高致病性禽流感在奶牛中传播和牛向人传播后,流感得到了高度关注。本文综述了甲型流感病毒(IAV)生物学的一般方面及其与哺乳动物宿主的相互作用,并讨论了开发疫苗以预防或减少IAV在牛乳腺中的感染及其通过牛奶传播的关键考虑因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
NPJ Vaccines
NPJ Vaccines Immunology and Microbiology-Immunology
CiteScore
11.90
自引率
4.30%
发文量
146
审稿时长
11 weeks
期刊介绍: Online-only and open access, npj Vaccines is dedicated to highlighting the most important scientific advances in vaccine research and development.
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