Mutagenicity, DNA Repair Gene Polymorphism, and Differentially Expressed Plasma Protein Fractions Among Textile Dyeing Workers.

Journal of occupational and environmental medicine Pub Date : 2025-02-01 Epub Date: 2024-11-19 DOI:10.1097/JOM.0000000000003272

Adel Al-Wehedy, Heba Eldegla, Noha M Hazem, Emily A Kamel, Nada M El-Hadidy, Radwa Sehsah

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Abstract

Objectives: This study aimed to assess mutagenicity biomarkers among Egyptian textile dyeing workers, their alteration with gene polymorphism, and the changes in plasma proteins' expression.

Methods: Using a detailed questionnaire, a comparative cross-sectional study was conducted on 212 workers (106 textile dyeing-exposed group and 106 control group). CBMN-Cyt assay, ERCC2 gene polymorphism, and plasma protein fractions were analyzed in workers' blood samples.

Results: Textile dye workers had significantly higher mutagenicity biomarkers than the control group. Mutant ERCC2 genotypes, dye exposure, exposure period, and formaldehyde levels significantly predicted mutagenicity biomarkers' levels. Dye-exposed workers also showed significant changes in plasma protein fractions.

Conclusions: Textile dyeing workers, particularly susceptible genotypes, are at mutagenic risk and have significant changes in plasma protein fractions. Those changes are usually the first detectable response to toxic exposures and can be useful as exposure biomarkers.

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纺织染色工人的致突变性、DNA修复基因多态性和血浆蛋白的差异表达。

目的：本研究旨在评估埃及纺织染色工人的致突变性生物标志物及其基因多态性的变化，以及血浆蛋白表达的变化。方法：采用详细的问卷调查方法，对212名工人（染整暴露组106名，对照组106名）进行对比横断面研究。对工人血液样本进行CBMN-Cyt测定、ERCC2基因多态性和血浆蛋白组分分析。结果：印染工人的致突变性生物标志物明显高于对照组。突变体ERCC2基因型、染料暴露、暴露时间和甲醛水平显著预测致突变性生物标志物水平。接触染料的工人血浆蛋白含量也有显著变化。结论：纺织印染工人，尤其是易感基因型，存在致突变风险，且血浆蛋白组分发生显著变化。这些变化通常是对有毒物质暴露的第一个可检测的反应，可以作为暴露的生物标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Journal of occupational and environmental medicine

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