Exploring the neuroprotective benefits of phytochemicals extracted from indigenous edible fruits in Bangladesh.

Q1 Health Professions Animal models and experimental medicine Pub Date : 2025-01-14 DOI:10.1002/ame2.12522
Sumon Roy, Sajib Chandra Roy, Mehrukh Zehravi, Sherouk Hussein Sweilam, Rajib Das, Mylsamy Palanisamy, Venkata Lakshamana Sagar Dantinapalli, Selvaraja Elumalai, Jeetendra Kumar Gupta, Mohammed Ali Alshehri, Mohammed Asiri, Irfan Ahmad, Mohamed H Nafady, Talha Bin Emran
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Abstract

The increasing incidence of neurodegenerative diseases (NDs) and the constraints of existing treatment methods have spurred a keen interest in investigating alternative therapies. Medicinal plants, renowned for their long-standing use in traditional medicine, offer a hopeful avenue for discovering new neuroprotective agents. This study emphasizes the potential neuroprotective characteristics of edible fruit plants in Bangladesh, specifically focusing on their traditional folk medicine uses for neurological disorders. This study provides an in-depth overview of the different types of edible fruit trees in Bangladesh and their phytochemicals, including flavonoids, terpenoids, and phenolic acids. This work examines the scientific data supporting the neuroprotective properties of bioactive chemicals from plants. It further explores the mechanisms by which these compounds work to counteract oxidative stress, decrease inflammation, and stimulate neurogenesis. Moreover, the study investigates toxicological characteristics and bioactive components of some fruits, emphasizing the importance of further investigation to measure their safety profile comprehensively. This thorough study highlights the potential benefits of Bangladesh's edible fruit trees as a rich source of neuroprotective chemicals. It also shows that additional research might lead to novel approaches for improving brain functioning and preventing NDs.

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探索从孟加拉国本土可食用水果中提取的植物化学物质的神经保护作用。
神经退行性疾病(NDs)发病率的增加和现有治疗方法的局限性促使人们对研究替代疗法产生了浓厚的兴趣。药用植物因其在传统医学中的长期应用而闻名,为发现新的神经保护剂提供了一条充满希望的途径。本研究强调了孟加拉国食用水果植物的潜在神经保护特性,特别关注其用于神经疾病的传统民间医学用途。本研究深入概述了孟加拉国不同类型的可食用果树及其植物化学物质,包括黄酮类、萜类和酚酸。这项工作考察了支持植物生物活性化学物质的神经保护特性的科学数据。它进一步探讨了这些化合物对抗氧化应激、减少炎症和刺激神经发生的机制。此外,本研究还研究了一些水果的毒理学特性和生物活性成分,强调了进一步研究以全面衡量其安全性的重要性。这项深入的研究强调了孟加拉国可食用果树作为神经保护化学物质的丰富来源的潜在好处。它还表明,进一步的研究可能会带来改善大脑功能和预防NDs的新方法。
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CiteScore
5.50
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0.00%
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审稿时长
12 weeks
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