Patterns of incident Burkitt lymphoma during the HIV epidemic among the Black African and White population in South Africa

IF 6.4 1区 医学 Q1 ONCOLOGY British Journal of Cancer Pub Date : 2025-01-14 DOI:10.1038/s41416-024-02937-8
Carole Metekoua, Yann Ruffieux, Judith Mwansa-Kambafwile, Patricia Kellett, Matthias Egger, Mazvita Muchengeti, Eliane Rohner, Tracey Wiggill
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Abstract

Burkitt lymphoma (BL) may be HIV-associated but data on BL trends in South Africa (SA), where HIV is highly prevalent, are scarce. We compared BL incidence trends over 36 years among Black African and White individuals. We included histologically diagnosed BL from the National Cancer Registry in SA between 1986–2021. We computed yearly age-standardised incidence rates (ASIR) by race, and annual percentage changes in ASIR using Joinpoint regression. Between 1986–2021, 2205 Black African (ASIR: 1.68/1,000,000; 95% confidence interval [CI] 1.63–1.73) and 366 White individuals (ASIR: 2.34/1,000,000; 95% CI 2.15–2.53) had incident BL. Median age at diagnosis increased over time, while the male proportion among those diagnosed declined. The ASIR among Black Africans increased from 1986–2012 and declined thereafter with BL incidence peaks shifting from children and elderly to middle-aged adults. Among White individuals, BL rates rose among all age groups over time. The BL epidemiology among Black Africans, with decreasing rates since 2012, may reflect SA’s evolving HIV epidemic. In contrast, BL rates among White individuals in SA and many high-income countries continue to increase over time. Further studies are needed to better understand the differences in BL epidemiology across geographic regions and population groups.

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南非非洲黑人和白人艾滋病流行期间伯基特淋巴瘤的发生模式。
背景:伯基特淋巴瘤(BL)可能与HIV相关,但在HIV高度流行的南非(SA),关于BL趋势的数据很少。我们比较了非洲黑人和白人36年来的BL发病率趋势。方法:我们纳入了1986-2021年间SA国家癌症登记处组织学诊断的BL。我们按种族计算了年年龄标准化发病率(ASIR),并使用关节点回归计算了ASIR的年百分比变化。结果:1986-2021年间,2205名黑非洲人(ASIR: 1.68/1,000,000;95%可信区间[CI] 1.63-1.73)和366名白人个体(ASIR: 2.34/1,000,000;95% CI 2.15-2.53)发生了BL。诊断时的中位年龄随着时间的推移而增加,而确诊患者中的男性比例下降。非洲黑人的ASIR在1986-2012年间呈上升趋势,此后呈下降趋势,发病高峰从儿童和老年人转移到中年人。在白人中,随着时间的推移,所有年龄组的BL发病率都在上升。结论:非洲黑人的BL流行病学自2012年以来呈下降趋势,可能反映了南非HIV流行的演变。相比之下,南非和许多高收入国家白人的BL发病率随着时间的推移而持续上升。需要进一步研究以更好地了解不同地理区域和人群之间BL流行病学的差异。
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来源期刊
British Journal of Cancer
British Journal of Cancer 医学-肿瘤学
CiteScore
15.10
自引率
1.10%
发文量
383
审稿时长
6 months
期刊介绍: The British Journal of Cancer is one of the most-cited general cancer journals, publishing significant advances in translational and clinical cancer research.It also publishes high-quality reviews and thought-provoking comment on all aspects of cancer prevention,diagnosis and treatment.
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