Cutoff points for handgrip strength in patients with liver cirrhosis: a multicenter study.

IF 3.6 3区医学 Q2 NUTRITION & DIETETICS European Journal of Clinical Nutrition Pub Date : 2025-01-14 DOI:10.1038/s41430-024-01563-0

Bárbara Chaves Santos, Bruna Cherubini Alves, Ana Luisa Ferreira Fonseca, Samanta Catherine Ferreira, Yani Gláucia Gomide Mizubuti, Camila Saueressig, Ramona Souza da Silva Baqueiro Boulhosa, Lívia Alves Amaral Santos, Carla de Magalhães Cunha, Andre Castro Lyra, Lucivalda Pereira Magalhães Oliveira, Rosângela Passos de Jesus, Fernando Gomes Romeiro, Valesca Dall'Alba, Vivian Cristine Luft, Maria Isabel Toulson Davisson Correia, Lívia Garcia Ferreira, Lucilene Rezende Anastácio

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Abstract

Objectives: This study aimed to define handgrip strength (HGS) cutoff points to predict 1-year mortality in adult patients with liver cirrhosis.

Methods: This is an analysis of cohort databases from four reference centers in Brazil. Inpatients or outpatients with cirrhosis and aged ≥18 years were included. The best cutoff values of HGS (highest value from three attempts with the non-dominant hand) for predicting 1-year mortality, stratified by sex and age, were established based on the sensitivity and specificity analyses. Adjusted Cox regression models were used to test the predictive value of low HGS.

Results: The study included 724 patients with cirrhosis, with a median age of 57.0 years (IQR: 50.0-63.0), 66.4% (n = 481) male. Most patients had alcoholic cirrhosis (n = 281; 38.8%), 400 (55.3%) were classified as Child-Pugh B or C, and 134 (18.5%) patients died after 1-year. The HGS cutoffs were ≤33 kgf and ≤12 kgf for men and women aged <60 years, respectively, and ≤22 kgf and ≤10 kgf for older men and women, respectively (sensitivity: 70.9%; specificity: 61.2%). Low HGS was associated with a 2.5-fold increase in the risk of 1-year mortality.

Conclusion: These cutoff points could be used to identify patients with a higher mortality risk.

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肝硬化患者握力的截止点：一项多中心研究。

目的：本研究旨在确定握力（HGS）截断点，以预测成年肝硬化患者1年死亡率。方法：这是对来自巴西四个参考中心的队列数据库的分析。纳入年龄≥18岁的住院或门诊肝硬化患者。基于敏感性和特异性分析，建立了HGS预测1年死亡率的最佳临界值（非优势手三次尝试的最高值），按性别和年龄分层。采用校正Cox回归模型检验低HGS的预测值。结果：研究纳入肝硬化患者724例，中位年龄57.0岁（IQR: 50.0 ~ 63.0），男性占66.4% （n = 481）。大多数患者为酒精性肝硬化(n = 281；Child-Pugh B、C级400例（55.3%），1年后死亡134例（18.5%）。老年男性和女性的HGS临界值分别为≤33 kgf和≤12 kgf。结论：这些临界值可用于鉴别死亡风险较高的患者。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European Journal of Clinical Nutrition 医学-营养学

CiteScore

10.60

自引率

2.10%

发文量

189

审稿时长

3-6 weeks

期刊介绍： The European Journal of Clinical Nutrition (EJCN) is an international, peer-reviewed journal covering all aspects of human and clinical nutrition. The journal welcomes original research, reviews, case reports and brief communications based on clinical, metabolic and epidemiological studies that describe methodologies, mechanisms, associations and benefits of nutritional interventions for clinical disease and health promotion. Topics of interest include but are not limited to: Nutrition and Health (including climate and ecological aspects) Metabolism & Metabolomics Genomics and personalized strategies in nutrition Nutrition during the early life cycle Health issues and nutrition in the elderly Phenotyping in clinical nutrition Nutrition in acute and chronic diseases The double burden of ''malnutrition'': Under-nutrition and Obesity Prevention of Non Communicable Diseases (NCD)