Notification of blood donors who test positive for transfusion-transmissible infections.

IF 1.8 4区 医学 Q3 HEMATOLOGY Vox Sanguinis Pub Date : 2025-01-14 DOI:10.1111/vox.13796
Sheila F O'Brien, Kiyuri Naicker, Lori Osmond, Kelly Holloway, Steven J Drews, Mark Bigham, Mindy Goldman
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Abstract

Background and objectives: Despite screening procedures, a few blood donors confirm positive for transfusion-transmissible infections and are deferred. Effective notification of laboratory results is essential to ensure that donors are advised of confirmed results and to seek medical care. Here we report results from post-notification interviews of Canadian Blood Services donors.

Materials and methods: Over 17 years, 2006-2022, all donors with confirmed positive results for hepatitis B virus (HBV), hepatitis C virus (HCV), human T-cell lymphotropic virus (HTLV) and syphilis were notified by registered mail of their result and advised to see a physician. In a separate communication, all donors were later invited to participate in a scripted interview asking whether they tested positive for an infection; if yes, which one, what their reaction was, whether they consulted a physician and whether public health contacted them. Frequencies of responses were calculated.

Results: Of 2654 donors with confirmed positive test results, 876 (33%) participated; 90% said they were informed of a positive test result. Of these, about a quarter did not know for which infection they were positive. Most were surprised, and some were sad or disappointed. Most saw a physician after notification (77%). About two-thirds with HBV or HCV said they were contacted by public health, slightly fewer (58%) with syphilis, 27% of those with HTLV.

Conclusion: Most donors recalled being notified and were aware of their positive test, but details of the infection were sometimes not understood or recalled, and not all donors consulted a physician about the infection.

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通知输血传播感染检测呈阳性的献血者。
背景和目的:尽管有筛查程序,但少数献血者确认输血传播感染呈阳性并被推迟。有效通知化验结果对于确保将确认结果告知捐赠者并寻求医疗护理至关重要。在这里,我们报告从通知后采访加拿大血液服务献血者的结果。材料和方法:在2006-2022年的17年中,所有乙型肝炎病毒(HBV)、丙型肝炎病毒(HCV)、人t细胞嗜淋巴病毒(HTLV)和梅毒确诊阳性的献血者都通过挂号邮件通知结果,并建议他们去看医生。在另一份单独的通讯中,所有捐赠者随后都被邀请参加一次事先安排好的采访,询问他们是否被检测出感染呈阳性;如果是,是哪一个,他们的反应是什么,他们是否咨询了医生,公共卫生部门是否联系了他们。计算反应频率。结果:在2654例检测结果确认阳性的献血者中,876例(33%)参与;90%的人表示他们被告知检测结果呈阳性。其中,大约四分之一的人不知道自己是哪种感染的阳性。大多数人感到惊讶,有些人感到悲伤或失望。大多数人在接到通知后去看医生(77%)。大约三分之二的乙肝病毒或丙肝病毒感染者表示,公共卫生部门与他们有过接触,梅毒感染者略少(58%),乙型肝炎病毒感染者为27%。结论:大多数献血者回忆说,他们收到了通知,知道自己的检测结果呈阳性,但感染的细节有时不清楚或回忆不起来,并非所有献血者都就感染咨询过医生。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Vox Sanguinis
Vox Sanguinis 医学-血液学
CiteScore
4.40
自引率
11.10%
发文量
156
审稿时长
6-12 weeks
期刊介绍: Vox Sanguinis reports on important, novel developments in transfusion medicine. Original papers, reviews and international fora are published on all aspects of blood transfusion and tissue transplantation, comprising five main sections: 1) Transfusion - Transmitted Disease and its Prevention: Identification and epidemiology of infectious agents transmissible by blood; Bacterial contamination of blood components; Donor recruitment and selection methods; Pathogen inactivation. 2) Blood Component Collection and Production: Blood collection methods and devices (including apheresis); Plasma fractionation techniques and plasma derivatives; Preparation of labile blood components; Inventory management; Hematopoietic progenitor cell collection and storage; Collection and storage of tissues; Quality management and good manufacturing practice; Automation and information technology. 3) Transfusion Medicine and New Therapies: Transfusion thresholds and audits; Haemovigilance; Clinical trials regarding appropriate haemotherapy; Non-infectious adverse affects of transfusion; Therapeutic apheresis; Support of transplant patients; Gene therapy and immunotherapy. 4) Immunohaematology and Immunogenetics: Autoimmunity in haematology; Alloimmunity of blood; Pre-transfusion testing; Immunodiagnostics; Immunobiology; Complement in immunohaematology; Blood typing reagents; Genetic markers of blood cells and serum proteins: polymorphisms and function; Genetic markers and disease; Parentage testing and forensic immunohaematology. 5) Cellular Therapy: Cell-based therapies; Stem cell sources; Stem cell processing and storage; Stem cell products; Stem cell plasticity; Regenerative medicine with cells; Cellular immunotherapy; Molecular therapy; Gene therapy.
期刊最新文献
Use of immunoglobulin G homeostatic set point and recovery time in plasmapheresis donor safety monitoring: A retrospective observational cohort study. An experimental comparison and user evaluation of three different dried plasma products. Artificial intelligence and transfusion education, research and practice: The view from the ISBT Clinical Transfusion Working Party. Transfusion efficacy of leucoreduced packed red blood cells prepared by two different methods: A randomized controlled trial in transfusion-dependent thalassaemia patients (FUEL trial). Notification of blood donors who test positive for transfusion-transmissible infections.
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