Dosimetric impact of arc simulation angular resolution in single-isocentre multi-target stereotactic radiosurgery.

IF 1.7 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Radiological Physics and Technology Pub Date : 2025-01-15 DOI:10.1007/s12194-024-00876-w
Perumal Murugan, Ravikumar Manickam, Tamilarasan Rajamanickam, Sivakumar Muthu, C Dinesan, Karthik Appunu, Abishake Murali
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Abstract

This study evaluates the dosimetric impact of arc simulation angular resolution in VMAT-based Single Isocentre Multiple Target (SIMT) SRS, focusing on their dependence on target size, isocentre distance, number of arcs, and arc type. A phantom study analysed angular resolution (0.5°, 1°, 2°) effects on dosimetric accuracy for PTVs of 0.5 cm, 1 cm, and 2 cm at distances of 2.5 cm, 5 cm, and 7.5 cm from the isocentre using conformal arc and VMAT plans. Clinical validation involved 32 patients with 2-8 brain metastases, comparing plans recalculated at 1° and 2° resolutions. Dosimetric parameters included: Dnear-Min, Dnear-Max, Dmean, Dmedian, TVPIV, CIPaddick, GI, and Brain-GTV 12 Gy. For the 0.5 cm diameter target located at 7.5 cm distance from isocentre, phantom results showed TVPIV, Dmean, and GI deviations of 7.91%, 1.8%, and 0.85 for single-conformal arcs, which decreased to 4.84%, 1.3%, and 0.77 with 4-conformal arcs, and 3.4%, 0.96%, and 0.5 for 4-arc VMAT. Deviations varied based on target size, isocentre distance, number of arcs, and arc type. Clinical results mirrored the phantom study, with maximum TVPIV and GI deviations of 2.76% and 0.65 for the smallest target (0.6 cm) located at 7.5 cm distance for four-arc VMAT. Other dosimetric parameters showed minimal variations (< 1%). Correlation analysis revealed strong associations between dosimetric differences, target size, and distance (r = 0.6-0.78 for small targets). MANOVA identified TVPIV as the only significant parameter (p = 0.01). A 1° angular resolution significantly improves dosimetric accuracy for small, distally located targets in SIMT SRS.

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弧模拟角分辨率在单等心多靶点立体定向放射手术中的剂量学影响。
本研究评估了基于vmat的单等心多目标(SIMT) SRS中弧模拟角分辨率对剂量学的影响,重点研究了它们与目标尺寸、等心距离、弧数和弧类型的依赖关系。一项幻影研究分析了角分辨率(0.5°,1°,2°)对距离等心2.5 cm, 5 cm和7.5 cm的ptv 0.5 cm, 1 cm和2 cm剂量学精度的影响,使用共形弧和VMAT计划。临床验证涉及32例2-8脑转移患者,比较在1°和2°分辨率下重新计算的计划。剂量学参数包括:Dnear-Min、Dnear-Max、Dmean、Dmedian、TVPIV、CIPaddick、GI和Brain-GTV 12 Gy。对于距离等心7.5 cm、直径0.5 cm的目标,单共形弧线的TVPIV、Dmean和GI偏差分别为7.91%、1.8%和0.85,4共形弧线的TVPIV、Dmean和GI偏差分别为4.84%、1.3%和0.77,4弧VMAT的TVPIV、Dmean和GI偏差分别为3.4%、0.96%和0.5。偏差根据目标大小、等心距离、圆弧数量和圆弧类型而变化。临床结果反映了幻影研究,四弧VMAT最小靶(0.6 cm)位于7.5 cm距离,TVPIV和GI偏差最大为2.76%,0.65。其他剂量学参数变化最小(PIV是唯一显著的参数(p = 0.01)。在SIMT SRS中,1°角分辨率显著提高了小的、远端定位目标的剂量学精度。
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来源期刊
Radiological Physics and Technology
Radiological Physics and Technology RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-
CiteScore
3.00
自引率
12.50%
发文量
40
期刊介绍: The purpose of the journal Radiological Physics and Technology is to provide a forum for sharing new knowledge related to research and development in radiological science and technology, including medical physics and radiological technology in diagnostic radiology, nuclear medicine, and radiation therapy among many other radiological disciplines, as well as to contribute to progress and improvement in medical practice and patient health care.
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