Changes in anaphylaxis trends and characteristics in emergency department admissions in Türkiye: From 2015 to 2021 based on the Ministry of Health database.

IF 3.9 2区 医学 Q2 ALLERGY World Allergy Organization Journal Pub Date : 2024-12-24 eCollection Date: 2025-01-01 DOI:10.1016/j.waojou.2024.101019
Elif Soyak Aytekin, Seda Şirin, Esra Kıratlı Nalbant, Naim Ata, Ahmet Sertçelik, Mustafa Mahir Ülgü, Şuayip Birinci, Koray Harmancı, Zülfikar Akelma
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Abstract

Background: The incidence of anaphylaxis is increasing worldwide. However, there is a lack of data on anaphylaxis trends in Türkiye. This study aims to analyse trends in anaphylaxis-related emergency department (ED) visits and examines factors associated with fatal anaphylaxis in Türkiye.

Methods: We retrospectively analyzed data from Türkiye's Ministry of Health database from 2015 to 2022. Codes from the International Classification of Diseases, 10th revision (ICD-10), were used to identify anaphylaxis.

Results: During the study period, a total 21,370 ED admissions for anaphylaxis were identified, and anaphylaxis admissions increased 1.23-fold from 3.90 to 4.79 per 105 population per year. The anaphylaxis trigger was unknown in 79.9% of cases, followed by drugs (11.7%), food (5.7%) and venom (2.7%). Epinephrine was administered in 49.6% of cases, and a total of 424 patients (2.1% of total cases) died. The frequency of intensive care unit (ICU) hospitalization increased 6.0-fold from 2015 to 2021, and age-adjusted average-weighted mortality rate for anaphylaxis was 0.66 per million. Older age, presence of asthma, and ICU hospitalization were found to be significantly associated with fatal anaphylaxis (p < 0.001 for all). Frequencies of death were 9.1% for venom anaphylaxis, 1.2% in drug anaphylaxis, and 0.2% for food anaphylaxis. Epinephrine autoinjector (EAI) was prescribed for 6.9% of all patients.

Conclusions: This is the first study of ED admissions for anaphylaxis using a large, nationwide data from Türkiye. Increasing numbers of ED admissions, ICU hospitalizations and mortality show that anaphylaxis is an important public health issue in Türkiye.

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根据卫生部数据库,2015年至2021年,泰国急诊科住院患者过敏反应趋势和特征的变化。
背景:过敏性反应的发病率在世界范围内呈上升趋势。然而,缺乏关于基耶病毒过敏反应趋势的数据。本研究旨在分析过敏相关急诊科(ED)就诊的趋势,并检查与基耶岛致死性过敏反应相关的因素。方法:回顾性分析2015年至2022年泰国卫生部数据库中的数据。使用国际疾病分类第十版(ICD-10)中的编码来识别过敏反应。结果:在研究期间,共有21370例因过敏反应入院,每年每105人的过敏反应入院人数从3.90人增加到4.79人,增加了1.23倍。79.9%的过敏反应触发因素未知,其次是药物(11.7%)、食物(5.7%)和毒液(2.7%)。49.6%的病例使用肾上腺素,死亡424例(占总病例的2.1%)。重症监护病房(ICU)住院频率从2015年到2021年增加了6.0倍,年龄调整后的过敏反应平均加权死亡率为0.66 /百万人。研究发现,年龄较大、哮喘存在和ICU住院与致死性过敏反应显著相关(p)。结论:这是首个使用来自t rkiye的大型全国性数据对因过敏反应入院的急诊科患者进行的研究。急诊科入院人数、ICU住院人数和死亡率的增加表明,过敏反应是一个重要的公共卫生问题。
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来源期刊
World Allergy Organization Journal
World Allergy Organization Journal Immunology and Microbiology-Immunology
CiteScore
9.10
自引率
5.90%
发文量
91
审稿时长
9 weeks
期刊介绍: The official pubication of the World Allergy Organization, the World Allergy Organization Journal (WAOjournal) publishes original mechanistic, translational, and clinical research on the topics of allergy, asthma, anaphylaxis, and clincial immunology, as well as reviews, guidelines, and position papers that contribute to the improvement of patient care. WAOjournal publishes research on the growth of allergy prevalence within the scope of single countries, country comparisons, and practical global issues and regulations, or threats to the allergy specialty. The Journal invites the submissions of all authors interested in publishing on current global problems in allergy, asthma, anaphylaxis, and immunology. Of particular interest are the immunological consequences of climate change and the subsequent systematic transformations in food habits and their consequences for the allergy/immunology discipline.
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