Human HKU1-reactive CD4 T cells are enriched for cytolytic potential that persists in older adults.

IF 5 2区 医学 Q2 IMMUNOLOGY Journal of Infectious Diseases Pub Date : 2025-01-15 DOI:10.1093/infdis/jiaf026
Chantelle L White, Katherine A Richards, Nelson Huertas, Jennifer L Nayak, Andrea J Sant
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Abstract

The emergence of SARS-CoV-2 increased interest in cellular immunity established by infections with human coronaviruses (HCoVs). Using PBMC from a cohort of human subjects collected prior to 2019, we assessed the abundance and phenotype of these CD4 T cells using cytokine Elispot assays. Unexpectedly, cytotoxic potential was uniquely enriched amongst HKU1-reactive CD4 T cells, as measured by quantification of granzyme producing cells. Also, although dramatic losses in HCoV-specific CD4 T cells abundance for OC43, NL63 and 229E-specific cells were observed in older subjects relative to younger adults, HKU1-reactive cells exhibited minimal age-dependent differences in this phenotype.

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人类hku1反应性CD4 T细胞富含细胞溶解潜能,这种潜能在老年人中持续存在。
SARS-CoV-2的出现增加了人们对人类冠状病毒(hcov)感染建立的细胞免疫的兴趣。使用2019年之前收集的人类受试者队列中的PBMC,我们使用细胞因子Elispot检测评估了这些CD4 T细胞的丰度和表型。出乎意料的是,通过颗粒酶产生细胞的定量测量,细胞毒性潜能在hku1反应性CD4 T细胞中独特地富集。此外,尽管与年轻人相比,在老年受试者中观察到OC43、NL63和229e特异性细胞的hcov特异性CD4 T细胞丰度显著下降,但hku1反应性细胞在这种表型中表现出最小的年龄依赖性差异。
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来源期刊
Journal of Infectious Diseases
Journal of Infectious Diseases 医学-传染病学
CiteScore
13.50
自引率
3.10%
发文量
449
审稿时长
2-4 weeks
期刊介绍: Published continuously since 1904, The Journal of Infectious Diseases (JID) is the premier global journal for original research on infectious diseases. The editors welcome Major Articles and Brief Reports describing research results on microbiology, immunology, epidemiology, and related disciplines, on the pathogenesis, diagnosis, and treatment of infectious diseases; on the microbes that cause them; and on disorders of host immune responses. JID is an official publication of the Infectious Diseases Society of America.
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