A distinct TAM subset mediates immunotherapy resistance in prostate cancer

IF 12.1 1区 医学 Q1 UROLOGY & NEPHROLOGY Nature Reviews Urology Pub Date : 2025-01-16 DOI:10.1038/s41585-025-00996-x
Maria Chiara Masone
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一个独特的TAM亚群介导前列腺癌的免疫治疗抵抗
免疫检查点抑制剂(ICI)在转移性去势抵抗性前列腺癌(mCRPC)患者中的疗效受到耐药性的阻碍。了解ICI耐药机制对提高治疗效果至关重要。发表在《自然》杂志上的一项新研究发现了一种独特的巨噬细胞亚群,随着疾病的进展,它的丰度增加,这是免疫治疗耐药性的原因。
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来源期刊
Nature Reviews Urology
Nature Reviews Urology 医学-泌尿学与肾脏学
CiteScore
12.50
自引率
2.60%
发文量
123
审稿时长
6-12 weeks
期刊介绍: Nature Reviews Urology is part of the Nature Reviews portfolio of journals.Nature Reviews' basic, translational and clinical content is written by internationally renowned basic and clinical academics and researchers. This journal targeted readers in the biological and medical sciences, from the postgraduate level upwards, aiming to be accessible to professionals in any biological or medical discipline. The journal features authoritative In-depth Reviews providing up-to-date information on topics within a field's history and development. Perspectives, News & Views articles, and the Research Highlights section offer topical discussions and opinions, filtering primary research from various medical journals. Covering a wide range of subjects, including andrology, urologic oncology, and imaging, Nature Reviews provides valuable insights for practitioners, researchers, and academics within urology and related fields.
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