{"title":"A distinct TAM subset mediates immunotherapy resistance in prostate cancer","authors":"Maria Chiara Masone","doi":"10.1038/s41585-025-00996-x","DOIUrl":null,"url":null,"abstract":"<p>Immune checkpoint inhibitor (ICI) efficacy in patients with metastatic castration-resistant prostate cancer (mCRPC) is hampered by resistance. Understanding the mechanisms underlying ICI resistance is crucial to improve therapeutic efficacy.</p><p>A new study published in <i>Nature</i> identified a distinct macrophage subset that shows increasing abundance as the disease progresses and that is responsible for immunotherapy resistance.</p>","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"13 1","pages":""},"PeriodicalIF":12.1000,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature Reviews Urology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1038/s41585-025-00996-x","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"UROLOGY & NEPHROLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Immune checkpoint inhibitor (ICI) efficacy in patients with metastatic castration-resistant prostate cancer (mCRPC) is hampered by resistance. Understanding the mechanisms underlying ICI resistance is crucial to improve therapeutic efficacy.
A new study published in Nature identified a distinct macrophage subset that shows increasing abundance as the disease progresses and that is responsible for immunotherapy resistance.
期刊介绍：
Nature Reviews Urology is part of the Nature Reviews portfolio of journals.Nature Reviews' basic, translational and clinical content is written by internationally renowned basic and clinical academics and researchers. This journal targeted readers in the biological and medical sciences, from the postgraduate level upwards, aiming to be accessible to professionals in any biological or medical discipline.
The journal features authoritative In-depth Reviews providing up-to-date information on topics within a field's history and development. Perspectives, News & Views articles, and the Research Highlights section offer topical discussions and opinions, filtering primary research from various medical journals.
Covering a wide range of subjects, including andrology, urologic oncology, and imaging, Nature Reviews provides valuable insights for practitioners, researchers, and academics within urology and related fields.
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