{"title":"A cocktail of kinase inhibitors that enhance the antitumor effects of CAR-T cell therapy","authors":"","doi":"10.1038/s41590-024-02049-8","DOIUrl":null,"url":null,"abstract":"In an unbiased high-throughput screen of 800 kinase inhibitors, we identified a cocktail of kinase inhibitors that increase the frequency of T memory stem cells for CAR-T cell therapy, resulting in improved antitumor effects both in vitro and in mouse models.","PeriodicalId":19032,"journal":{"name":"Nature Immunology","volume":"61 1","pages":""},"PeriodicalIF":27.7000,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature Immunology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1038/s41590-024-02049-8","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"IMMUNOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
In an unbiased high-throughput screen of 800 kinase inhibitors, we identified a cocktail of kinase inhibitors that increase the frequency of T memory stem cells for CAR-T cell therapy, resulting in improved antitumor effects both in vitro and in mouse models.
期刊介绍：
Nature Immunology is a monthly journal that publishes the highest quality research in all areas of immunology. The editorial decisions are made by a team of full-time professional editors. The journal prioritizes work that provides translational and/or fundamental insight into the workings of the immune system. It covers a wide range of topics including innate immunity and inflammation, development, immune receptors, signaling and apoptosis, antigen presentation, gene regulation and recombination, cellular and systemic immunity, vaccines, immune tolerance, autoimmunity, tumor immunology, and microbial immunopathology. In addition to publishing significant original research, Nature Immunology also includes comments, News and Views, research highlights, matters arising from readers, and reviews of the literature. The journal serves as a major conduit of top-quality information for the immunology community.
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