{"title":"Markers help to predict dementia with Lewy bodies","authors":"Ian Fyfe","doi":"10.1038/s41582-025-01058-x","DOIUrl":null,"url":null,"abstract":"<p>Biomarkers of Alzheimer disease (AD) pathology can predict the development of dementia with Lewy bodies (DLB) in people with idiopathic REM sleep behaviour disorder (iRBD), new research has shown. Levels of amyloid-β<sub>40</sub> (Aβ<sub>40</sub>), Aβ<sub>42</sub> and phosphorylated tau-181 (pTau181) were measured in blood from 142 people with iRBD. Among people who went on to develop DLB, the ratio of Aβ<sub>40</sub> to Aβ<sub>42</sub> was lower and the levels of pTau181 were higher than among people who did not develop DLB.</p>","PeriodicalId":19085,"journal":{"name":"Nature Reviews Neurology","volume":"54 1","pages":""},"PeriodicalIF":28.2000,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature Reviews Neurology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1038/s41582-025-01058-x","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Biomarkers of Alzheimer disease (AD) pathology can predict the development of dementia with Lewy bodies (DLB) in people with idiopathic REM sleep behaviour disorder (iRBD), new research has shown. Levels of amyloid-β40 (Aβ40), Aβ42 and phosphorylated tau-181 (pTau181) were measured in blood from 142 people with iRBD. Among people who went on to develop DLB, the ratio of Aβ40 to Aβ42 was lower and the levels of pTau181 were higher than among people who did not develop DLB.
期刊介绍：
Nature Reviews Neurology aims to be the premier source of reviews and commentaries for the scientific and clinical communities we serve. We want to provide an unparalleled service to authors, referees, and readers, and we work hard to maximize the usefulness and impact of each article. The journal publishes Research Highlights, Comments, News & Views, Reviews, Consensus Statements, and Perspectives relevant to researchers and clinicians working in the field of neurology. Our broad scope ensures that the work we publish reaches the widest possible audience. Our articles are authoritative, accessible, and enhanced with clearly understandable figures, tables, and other display items. This page gives more detail about the aims and scope of the journal.
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