{"title":"Understanding the roles of the WFDC cluster in sperm development and function","authors":"Annette Fenner","doi":"10.1038/s41585-025-00999-8","DOIUrl":null,"url":null,"abstract":"<p>A study in <i>Proceedings of the National Academy of Sciences</i> has elucidated the roles of the whey acidic protein four-disulfide core (WFDC) gene cluster in spermatogenesis and sperm function.</p><p>The fact that this reproductive-tract-specific cluster — comprising 11 genes in humans (<i>SPINT3</i>, <i>WFDC6</i>, <i>EPPIN</i>, <i>WFDC8</i>, <i>WFDC9</i>, <i>WFDC10A</i>, <i>WFDC11</i>, <i>WFDC10B</i>, <i>WFDC13</i>, <i>SPINT4</i> and <i>WFDC3)</i> and 13 in rodents — is so well conserved across species suggests combined critical functions of the cluster.</p>","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"5 1","pages":""},"PeriodicalIF":12.1000,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature Reviews Urology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1038/s41585-025-00999-8","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"UROLOGY & NEPHROLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
A study in Proceedings of the National Academy of Sciences has elucidated the roles of the whey acidic protein four-disulfide core (WFDC) gene cluster in spermatogenesis and sperm function.
The fact that this reproductive-tract-specific cluster — comprising 11 genes in humans (SPINT3, WFDC6, EPPIN, WFDC8, WFDC9, WFDC10A, WFDC11, WFDC10B, WFDC13, SPINT4 and WFDC3) and 13 in rodents — is so well conserved across species suggests combined critical functions of the cluster.
期刊介绍：
Nature Reviews Urology is part of the Nature Reviews portfolio of journals.Nature Reviews' basic, translational and clinical content is written by internationally renowned basic and clinical academics and researchers. This journal targeted readers in the biological and medical sciences, from the postgraduate level upwards, aiming to be accessible to professionals in any biological or medical discipline.
The journal features authoritative In-depth Reviews providing up-to-date information on topics within a field's history and development. Perspectives, News & Views articles, and the Research Highlights section offer topical discussions and opinions, filtering primary research from various medical journals.
Covering a wide range of subjects, including andrology, urologic oncology, and imaging, Nature Reviews provides valuable insights for practitioners, researchers, and academics within urology and related fields.
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