{"title":"Brain stimulation aids walking after spinal injury","authors":"Ian Fyfe","doi":"10.1038/s41582-025-01057-y","DOIUrl":null,"url":null,"abstract":"<p>In a new study, deep brain stimulation (DBS) of the lateral hypothalamus facilitated recovery after spinal cord injury (SCI) in rodents and humans. The researchers identified glutamatergic neurons in the lateral hypothalamus as a therapeutic target from a brain atlas of neurons involved in recovery of walking. Stimulation of these neurons in mice and rats with SCI improved walking and led to a durable improvement in recovery. Application of the same approach in two people with incomplete SCI also improved walking and supported longer-term recovery when combined with rehabilitation. Further trials are now needed to establish the safety and efficacy of the approach.</p>","PeriodicalId":19085,"journal":{"name":"Nature Reviews Neurology","volume":"45 1","pages":""},"PeriodicalIF":28.2000,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature Reviews Neurology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1038/s41582-025-01057-y","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
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Abstract
In a new study, deep brain stimulation (DBS) of the lateral hypothalamus facilitated recovery after spinal cord injury (SCI) in rodents and humans. The researchers identified glutamatergic neurons in the lateral hypothalamus as a therapeutic target from a brain atlas of neurons involved in recovery of walking. Stimulation of these neurons in mice and rats with SCI improved walking and led to a durable improvement in recovery. Application of the same approach in two people with incomplete SCI also improved walking and supported longer-term recovery when combined with rehabilitation. Further trials are now needed to establish the safety and efficacy of the approach.
期刊介绍：
Nature Reviews Neurology aims to be the premier source of reviews and commentaries for the scientific and clinical communities we serve. We want to provide an unparalleled service to authors, referees, and readers, and we work hard to maximize the usefulness and impact of each article. The journal publishes Research Highlights, Comments, News & Views, Reviews, Consensus Statements, and Perspectives relevant to researchers and clinicians working in the field of neurology. Our broad scope ensures that the work we publish reaches the widest possible audience. Our articles are authoritative, accessible, and enhanced with clearly understandable figures, tables, and other display items. This page gives more detail about the aims and scope of the journal.
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