Mengzhe Pan , Feng-Wei Guo , Xinjie Sun , Jie Zhang , Wei Lu , Lubin Xu , Fangzhi Hu , Shuai-Shuai Li
{"title":"Divergent application of 5-amino-isoxazoles for the construction of nitrogen heterocycles via the hydride transfer strategy†","authors":"Mengzhe Pan , Feng-Wei Guo , Xinjie Sun , Jie Zhang , Wei Lu , Lubin Xu , Fangzhi Hu , Shuai-Shuai Li","doi":"10.1039/d4qo02059f","DOIUrl":null,"url":null,"abstract":"<div><div>The hydride transfer-enabled divergent application of 5-amino-isoxazoles for the controllable construction of diverse tetrahydroquinolines and tetrahydroquinazolines was disclosed unprecedentedly by the process of ring-cleavage/Beckmann rearrangement, dearomative-spirocyclization, or <em>N</em>,<em>N</em>′-dialkylation of the amino group with the employment of different Lewis acids.</div></div>","PeriodicalId":94379,"journal":{"name":"Organic chemistry frontiers : an international journal of organic chemistry","volume":"12 6","pages":"Pages 1867-1873"},"PeriodicalIF":0.0000,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Organic chemistry frontiers : an international journal of organic chemistry","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/org/science/article/pii/S2052412925000397","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
The hydride transfer-enabled divergent application of 5-amino-isoxazoles for the controllable construction of diverse tetrahydroquinolines and tetrahydroquinazolines was disclosed unprecedentedly by the process of ring-cleavage/Beckmann rearrangement, dearomative-spirocyclization, or N,N′-dialkylation of the amino group with the employment of different Lewis acids.
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