Neural deterioration and compensation in visual short-term memory among individuals with amnestic mild cognitive impairment

IF 11.1 1区医学 Q1 CLINICAL NEUROLOGY Alzheimer's & Dementia Pub Date : 2025-01-17 DOI:10.1002/alz.14475

Ye Xie, Tinghao Zhao, Wei Zhang, Qi Chen, Anqi Qiu, Yunxia Li, Yixuan Ku

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Abstract

INTRODUCTION

Visual short-term memory (VSTM) is a critical indicator of Alzheimer's disease (AD), but whether its neural substrates could adapt to early disease progression and contribute to cognitive resilience in amnestic mild cognitive impairment (aMCI) has been unclear.

METHODS

Fifty-five aMCI patients and 68 normal controls (NC) performed a change-detection task and underwent multimodal neuroimaging scanning.

RESULTS

Among the atrophic brain regions in aMCI, VSTM performance correlated with the volume of the right prefrontal cortex (PFC) but not the medial temporal lobe (MTL), and this correlation was mainly present in patients with greater MTL atrophy. Furthermore, VSTM was primarily correlated with frontal structural connectivity in aMCI but was correlated with more distributed frontal and MTL connectivity in NC.

DISCUSSION

This study provided evidence on neural adaptation in the precursor stages of AD, highlighting the compensatory role of PFC as MTL deteriorated and suggesting potential targets in early intervention for cognitive preservation.

Highlights

Atrophic left medial temporal lobe (MTL) no longer correlated with visual short-term memory (VSTM) in amnestic mild cognitive impairment (aMCI).
Atrophic right middle frontal area continued to correlate with VSTM in aMCI.
Frontal brain–behavior correlation was mainly present in the aMCI subgroup with greater medial temporal lobe (MTL) atrophy.
Reliance of VSTM on frontal connectivity increased in compensation for MTL dysfunction.

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遗忘性轻度认知障碍患者视觉短期记忆的神经退化和代偿

视觉短期记忆（Visual short-term memory， VSTM）是阿尔茨海默病（Alzheimer's disease， AD）的一个重要指标，但其神经基质是否能够适应早期疾病进展，并有助于遗忘性轻度认知障碍（aMCI）的认知恢复，目前尚不清楚。

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来源期刊

Alzheimer's & Dementia 医学-临床神经学

CiteScore

14.50

自引率

5.00%

发文量

299

审稿时长

3 months

期刊介绍： Alzheimer's & Dementia is a peer-reviewed journal that aims to bridge knowledge gaps in dementia research by covering the entire spectrum, from basic science to clinical trials to social and behavioral investigations. It provides a platform for rapid communication of new findings and ideas, optimal translation of research into practical applications, increasing knowledge across diverse disciplines for early detection, diagnosis, and intervention, and identifying promising new research directions. In July 2008, Alzheimer's & Dementia was accepted for indexing by MEDLINE, recognizing its scientific merit and contribution to Alzheimer's research.