An organoid model with all three pancreatic lineages resembles fetal pancreas

IF 41.7 1区 生物学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Nature biotechnology Pub Date : 2025-01-17 DOI:10.1038/s41587-024-02537-0
Iris Marchal
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具有三种胰腺谱系的类器官模型与胎儿胰腺相似
在许多类器官技术的应用中,提高模型的复杂性以更接近天然组织是一个主要目标。这就是胰腺类器官的情况,到目前为止,它们还没有重现人类同类中存在的全部细胞类型。在《细胞》杂志上发表的一篇论文中,Andersson-Rolf等人介绍了一种更接近于模仿胎儿阶段人类胰腺的类器官模型。作者从妊娠14 ~ 16周的胎儿胰腺组织中生成了人胎儿胰腺类器官(hfPOs)。类器官包含三个主要的上皮区室-腺泡细胞,导管细胞和内分泌细胞-并且可以长期培养,超过2年。对hfPO细胞的表征表明,它们具有与人类胎儿胰腺组织相似的转录谱,并形成了功能酶和激素,模拟了胰腺发育的早期阶段。一些腺泡细胞表现出进一步成熟的迹象,这表明存在储存消化酶的深色酶原颗粒。
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来源期刊
Nature biotechnology
Nature biotechnology 工程技术-生物工程与应用微生物
CiteScore
63.00
自引率
1.70%
发文量
382
审稿时长
3 months
期刊介绍: Nature Biotechnology is a monthly journal that focuses on the science and business of biotechnology. It covers a wide range of topics including technology/methodology advancements in the biological, biomedical, agricultural, and environmental sciences. The journal also explores the commercial, political, ethical, legal, and societal aspects of this research. The journal serves researchers by providing peer-reviewed research papers in the field of biotechnology. It also serves the business community by delivering news about research developments. This approach ensures that both the scientific and business communities are well-informed and able to stay up-to-date on the latest advancements and opportunities in the field. Some key areas of interest in which the journal actively seeks research papers include molecular engineering of nucleic acids and proteins, molecular therapy, large-scale biology, computational biology, regenerative medicine, imaging technology, analytical biotechnology, applied immunology, food and agricultural biotechnology, and environmental biotechnology. In summary, Nature Biotechnology is a comprehensive journal that covers both the scientific and business aspects of biotechnology. It strives to provide researchers with valuable research papers and news while also delivering important scientific advancements to the business community.
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