Flower-like gap-enhanced Raman tags wrapped with polydopamine-functionalized MoS2 nanosheets for phototheranostic nanoplatform

IF 3.5 3区 材料科学 Q2 MATERIALS SCIENCE, MULTIDISCIPLINARY Journal of Materials Science Pub Date : 2025-01-08 DOI:10.1007/s10853-024-10532-8
Ming Chen, Xing Zhao, Bin Wang, Da Li, Xiaoxuan Xu, Hongliang Liu, Siwen Ai, Lu Sun
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Abstract

Phototheranostic nanoplatforms that perform simultaneous optical imaging and phototherapy through light activation are considered a promising approach for early diagnosis, surgical guidance, and precision treatment of cancer. In this work, we develop a novel flower-like gap-enhanced Raman tags (for brief, PMF-GERTs) wrapped with polydopamine (PDA)-functionalized molybdenum disulfide (MoS2) nanosheets. In PMF-GERTs, 4,4′-biphenyldithiol (BPDT) Raman reporter molecules are embedded in the nanogap between the gold core and the flower-like shell, and PDA-functionalized MoS2 nanosheets (PDA/MoS2) were wrapped on the surface of the flower-shaped shell. Photothermal and photodynamic experiments show that PDA/MoS2 nanosheets significantly improve the photothermal performance and photodynamic response ability of Raman tags in the NIR-II region. Under the irradiation of 1064 nm laser (1 W/cm2), the PMF-GERTs solution can heat up to 66 °C within 300 s, and the photothermal conversion efficiency reaches 43.6%. Moreover, PMF-GERT also has excellent photothermal stability and photodynamic properties and can perform effective phototherapy on 4T1 tumor cells. In Raman spectra and mapping imaging experiments, PMF-GERTs have strong enhanced Raman signals, lower detection thresholds and long-time physiological environment stability (72 h). In addition, PMF-GETRs also have excellent performance in simulating biological tissues and biological Raman mapping imaging. This novel Raman tag is expected to be used to develop phototheranostic nanoplatform that integrates Raman imaging diagnosis and photothermal and photodynamic therapy.

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用聚多巴胺功能化二硫化钼纳米片包裹的花状缝隙增强拉曼标签光疗纳米平台
光治疗纳米平台通过光激活同时进行光学成像和光治疗,被认为是早期诊断、手术指导和精确治疗癌症的一种有前途的方法。在这项工作中,我们开发了一种新型的花状间隙增强拉曼标签(简称PMF-GERTs),该标签由聚多巴胺(PDA)功能化二硫化钼(MoS2)纳米片包裹。在PMF-GERTs中,4,4 ' -联苯二硫醇(BPDT)拉曼报告分子嵌入在金核和花状壳之间的纳米间隙中,PDA功能化的MoS2纳米片(PDA/MoS2)包裹在花状壳的表面。光热和光动力实验表明,PDA/MoS2纳米片显著提高了NIR-II区拉曼标签的光热性能和光动力响应能力。在1064 nm激光(1 W/cm2)照射下,PMF-GERTs溶液可在300 s内加热至66℃,光热转换效率达到43.6%。此外,PMF-GERT还具有优异的光热稳定性和光动力学特性,可对4T1肿瘤细胞进行有效的光疗。在拉曼光谱和测绘成像实验中,PMF-GERTs具有较强的拉曼信号增强、较低的检测阈值和较长的生理环境稳定性(72 h)。此外,PMF-GETRs在模拟生物组织和生物拉曼测绘成像方面也具有优异的性能。这种新颖的拉曼标签有望用于开发集成拉曼成像诊断和光热和光动力治疗的光治疗纳米平台。图形抽象
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Sodium borohydride
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ascorbic acid
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sodium chloride
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来源期刊
Journal of Materials Science
Journal of Materials Science 工程技术-材料科学:综合
CiteScore
7.90
自引率
4.40%
发文量
1297
审稿时长
2.4 months
期刊介绍: The Journal of Materials Science publishes reviews, full-length papers, and short Communications recording original research results on, or techniques for studying the relationship between structure, properties, and uses of materials. The subjects are seen from international and interdisciplinary perspectives covering areas including metals, ceramics, glasses, polymers, electrical materials, composite materials, fibers, nanostructured materials, nanocomposites, and biological and biomedical materials. The Journal of Materials Science is now firmly established as the leading source of primary communication for scientists investigating the structure and properties of all engineering materials.
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