A. V. Bychkova, A. A. Markova, M. T. Nguyen, M. A. Gradova, M. G. Gorobets, M. V. Motyakin, M. I. Abdullina, A. V. Toroptseva, V. A. Kuzmin
{"title":"Nanosized Platform Based on Magnetic Nanoparticles for Photodynamic Therapy in Oncology","authors":"A. V. Bychkova, A. A. Markova, M. T. Nguyen, M. A. Gradova, M. G. Gorobets, M. V. Motyakin, M. I. Abdullina, A. V. Toroptseva, V. A. Kuzmin","doi":"10.1134/S199079312470129X","DOIUrl":null,"url":null,"abstract":"<p>Hybrid nanosystems based on iron oxide nanoparticles (IONPs) and human serum albumin (HSA) were synthesized. The size and composition of HSA@IONP nanosystems were characterized using UV/visible spectrophotometry (particularly, using the Bradford protein assay), dynamic light scattering (DLS), and electron magnetic resonance. The dark and photoinduced cytotoxicity of these systems were studied using methylene blue (MB) as a model photosensitizer (PS). The analysis of the survival of cultured tumor cells of the human breast adenocarcinoma line MCF-7 showed an increase in photoinduced cytotoxicity upon excitation of the PS accumulated by cells due to delivery via the nanosystems, compared to the free PS in equivalent concentrations. HSA@IONPs are discussed as a promising platform for the targeted delivery of a PS to tumor cells.</p>","PeriodicalId":768,"journal":{"name":"Russian Journal of Physical Chemistry B","volume":"18 6","pages":"1619 - 1625"},"PeriodicalIF":1.4000,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Russian Journal of Physical Chemistry B","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1134/S199079312470129X","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"PHYSICS, ATOMIC, MOLECULAR & CHEMICAL","Score":null,"Total":0}
引用次数: 0
Abstract
Hybrid nanosystems based on iron oxide nanoparticles (IONPs) and human serum albumin (HSA) were synthesized. The size and composition of HSA@IONP nanosystems were characterized using UV/visible spectrophotometry (particularly, using the Bradford protein assay), dynamic light scattering (DLS), and electron magnetic resonance. The dark and photoinduced cytotoxicity of these systems were studied using methylene blue (MB) as a model photosensitizer (PS). The analysis of the survival of cultured tumor cells of the human breast adenocarcinoma line MCF-7 showed an increase in photoinduced cytotoxicity upon excitation of the PS accumulated by cells due to delivery via the nanosystems, compared to the free PS in equivalent concentrations. HSA@IONPs are discussed as a promising platform for the targeted delivery of a PS to tumor cells.
期刊介绍：
Russian Journal of Physical Chemistry B: Focus on Physics is a journal that publishes studies in the following areas: elementary physical and chemical processes; structure of chemical compounds, reactivity, effect of external field and environment on chemical transformations; molecular dynamics and molecular organization; dynamics and kinetics of photoand radiation-induced processes; mechanism of chemical reactions in gas and condensed phases and at interfaces; chain and thermal processes of ignition, combustion and detonation in gases, two-phase and condensed systems; shock waves; new physical methods of examining chemical reactions; and biological processes in chemical physics.
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